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Comment
. 2020 Apr 9;20(3):154-156.
doi: 10.1177/1535759720916445. eCollection 2020 May-Jun.

Ictal Inhibition: Sync Globally, Slack Locally

Kyle P Lillis
Comment

Ictal Inhibition: Sync Globally, Slack Locally

Kyle P Lillis. Epilepsy Curr. .
No abstract available

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Figures

Figure 1.
Figure 1.
Neurons in the ictal core receive strong glutamatergic input from the locally propagating seizure. This drives interneurons into depolarization block, while principal neurons fire at a high rate. Excitatory neurons in the ictal core provide synchronous weak drive to distant principal cells and interneurons. Feedback inhibition in these distal networks generates an oscillation that is synchronized with spiking in the ictal core.
See this image and copyright information in PMC

Comment on

  • Role of paroxysmal depolarization in focal seizure activity.
    Tryba AK, Merricks EM, Lee S, Pham T, Cho S, Nordli DR Jr, Eissa TL, Goodman RR, McKhann GM Jr, Emerson RG, Schevon CA, van Drongelen W. Tryba AK, et al. J Neurophysiol. 2019 Nov 1;122(5):1861-1873. doi: 10.1152/jn.00392.2019. Epub 2019 Aug 28. J Neurophysiol. 2019. PMID: 31461373 Free PMC article. Review.

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