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. 2021 Dec;35(23):5125-5131.
doi: 10.1080/14786419.2020.1782405. Epub 2020 Jun 19.

Traphanoside GO1, a new triterpenoid saponin from the aerial parts of Glinus oppositifolius with the inhibitory effect on PGE2 production in LPS-induced HepG2 cells

Do Thi Ha  1 , Nguyen Thi Thu  1 , Tran Thanh Ha  1 , Vu Huong Thuy  2 , Nguyen Huy Van  2 , Tran Quang Luc  2 , Nguyen Thi Vinh Hue  2
Affiliations

Traphanoside GO1, a new triterpenoid saponin from the aerial parts of Glinus oppositifolius with the inhibitory effect on PGE2 production in LPS-induced HepG2 cells

Do Thi Ha et al. Nat Prod Res. 2021 Dec.

Abstract

A new saponin, 3-O-[α-ʟ-rhamnosyl-(1→3)-β-D-glucopyranosyl]-28-O-β-D-glucopyranosyl serjanic acid (Traphanoside GO1, 11) along with eleven compounds (1-10 and 12) were isolated from the aerial parts of Glinus oppositifolius. The structures of all isolates were elucidated by analyzing extensive 1 D- and 2 D-NMR and HR-ESI-MS, comparing with reported literature data. Compounds 7-8, 10-11, and 90% ethanol extract (GOE90) were evaluated for the inhibitory effect on PGE2 production from activated HepG2 cells. Among these, new compound 11 showed the most potent inhibitory activity by suppressing LPS-induced PGE2 production on the HepG2 cells.

Keywords: 3-O-[α-ʟ-rhamnosyl-(1→3)-β-D-glucopyranosyl]-28-O-β-D-glucopyranosyl serjanic acid; Glinus oppositifolius; HepG2 cell; PGE2; Traphanoside GO1.

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