A rationale for blocking thromboinflammation in COVID-19 with Btk inhibitors

Affiliations

¹ Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham , Birmingham, UK.
² Department of Medicine and Cardiovascular Institute, University of Pennsylvania , Philadelphia, Pennsylvania, USA.
³ Centre for Liver Research, Institute of Immunology and Inflammation, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, College of Medical and Dental Sciences, University of Birmingham , Birmingham, UK.
⁴ Centre of Membrane Proteins and Receptors, The Universities of Birmingham and Nottingham , The Midlands, UK.

Free article

Comment

Phillip Lr Nicolson et al. Platelets. 2020.

Free article

. 2020 Jul 3;31(5):685-690.

doi: 10.1080/09537104.2020.1775189. Epub 2020 Jun 19.

¹ Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham , Birmingham, UK.
² Department of Medicine and Cardiovascular Institute, University of Pennsylvania , Philadelphia, Pennsylvania, USA.
³ Centre for Liver Research, Institute of Immunology and Inflammation, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, College of Medical and Dental Sciences, University of Birmingham , Birmingham, UK.
⁴ Centre of Membrane Proteins and Receptors, The Universities of Birmingham and Nottingham , The Midlands, UK.

No abstract available

Keywords: Btk; COVID-19; platelets; thromboinflammation.

Comment in

Selective inhibition of thromboinflammation in COVID-19 by Btk inhibitors.
Siess W, Hundelshausen PV, Lorenz R. Siess W, et al. Platelets. 2020 Nov 16;31(8):989-992. doi: 10.1080/09537104.2020.1809647. Epub 2020 Sep 6. Platelets. 2020. PMID: 32892684 No abstract available.

Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis.
Ciceri F, Beretta L, Scandroglio AM, Colombo S, Landoni G, Ruggeri A, Peccatori J, D'Angelo A, De Cobelli F, Rovere-Querini P, Tresoldi M, Dagna L, Zangrillo A. Ciceri F, et al. Crit Care Resusc. 2020 Apr 15;22(2):95-97. doi: 10.51893/2020.2.pov2. Online ahead of print. Crit Care Resusc. 2020. PMID: 32294809 Free PMC article.
Thromboinflammation and the hypercoagulability of COVID-19.
Connors JM, Levy JH. Connors JM, et al. J Thromb Haemost. 2020 Jul;18(7):1559-1561. doi: 10.1111/jth.14849. Epub 2020 May 26. J Thromb Haemost. 2020. PMID: 32302453 Free PMC article. No abstract available.