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Meta-Analysis
. 2020 Jun 18;18(1):191.
doi: 10.1186/s12955-020-01449-2.

Comparisons of quality of life between patients underwent peritoneal dialysis and hemodialysis: a systematic review and meta-analysis

Anan Chuasuwan  1   2 , Siriporn Pooripussarakul  1 , Ammarin Thakkinstian  1 , Atiporn Ingsathit  1   3 , Oraluck Pattanaprateep  4
Affiliations
Meta-Analysis

Comparisons of quality of life between patients underwent peritoneal dialysis and hemodialysis: a systematic review and meta-analysis

Anan Chuasuwan et al. Health Qual Life Outcomes. .

Abstract

Objective: End-stage renal disease (ESRD) leads to renal replacement therapy and certainly has an impact on patients' health-related quality of life (HRQoL). This study aimed to review and compare the HRQoL between peritoneal dialysis (PD) and hemodialysis (HD) patients using the 36-Item Short Form Health Survey (SF-36), EuroQoL-5-dimension (EQ-5D) and the Kidney Disease Quality of Life Instrument (KDQOL).

Methodology: Systematic review was conducted by identify relevant studies through MEDLINE and SCOPUS up to April 2017. Studies were eligible with following criteria: studied in ESRD patients, compare any pair of renal replacement modalities, and reported HRQoL. The unstandardized mean differences (USMD) of HRQoL among modalities were calculated and pooled using a random-effect models if heterogeneity was present, otherwise a fixed-effect model was applied.

Results: A total of twenty-one studies were included with 29,000 participants. Of them, mean age and percent male were 48.1 years and 45.1, respectively. The pooled USMD (95% CI) of SF-36 between PD and HD (base) were 1.86 (0.47, 3.24) and 0.42 (- 1.99, 2.82) for mental component and physical component summary scores, respectively. For EQ-5D, the pooled USMD of utility and visual analogue scale (VAS) score were 0.02 (- 0.06, 0.10) and 3.56 (1.73, 5.39), respectively. The pooled USMD of KDQOL were 9.67 (5.67, 13.68), 6.71 (- 5.92, 19.32) 6.30 (- 0.41, 12.18), 2.35 (- 4.35, 9.04), 2.10 (0.07, 4.13), and 1.21 (- 2.98, 5.40) for burden of kidney disease, work status, effects of kidney disease, quality of social interaction, symptoms, and cognitive function.

Conclusion: Patients with chronic kidney disease (CKD) stage 5 or ESRD treated with PD had better generic HRQoL measured by SF-36 and EQ-5D than HD patients. In addition, PD had higher specific HRQoL by KDQOL than HD patients in subdomain of physical functioning, role limitations due to emotional problems, effects and burden of kidney disease.

Keywords: EQ-5D; Health-related quality of life; Hemodialysis; KDQOL; Peritoneal dialysis.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of study selection
Fig. 2
Fig. 2
Estimation of pooled USMD of SF-36 between PD and HD
Fig. 3
Fig. 3
Estimation of pooled USMD of EQ5D between PD and HD
Fig. 4
Fig. 4
Estimation of pooled USMD of KDQOL between PD and HD
See this image and copyright information in PMC

References

    1. Altunoglu A, Yavuz D, Canoz MB, et al. Relationship between inflammation and sex hormone profile in female patients receiving different types of renal replacement therapy. Transplant Proc. 2014;46(5):1585–1590. - PubMed
    1. Kostro JZ, Hellmann A, Kobiela J, et al. Quality of life after kidney transplantation: a prospective study. Transplant Proc. 2016;48(1):50–54. - PubMed
    1. Kovacs AZ, Molnar MZ, Szeifert L, et al. Sleep disorders, depressive symptoms and health-related quality of life--a cross-sectional comparison between kidney transplant recipients and waitlisted patients on maintenance dialysis. Nephrol Dial Transplant. 2011;26(3):1058–1065. - PubMed
    1. Kalender B, Ozdemir AC, Dervisoglu E, et al. Quality of life in chronic kidney disease: effects of treatment modality, depression, malnutrition and inflammation. Int J Clin Pract. 2007;61(4):569–576. - PubMed
    1. Kim H, An JN, Kim DK, et al. Elderly peritoneal dialysis compared with elderly hemodialysis patients and younger peritoneal dialysis patients: Competing risk analysis of a Korean prospective cohort study. PLoS One. 2015;10(6):e0131393. 10.1371/journal.pone.0131393. eCollection 2015. - PMC - PubMed