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. 2020 Aug;103(2):558-560.
doi: 10.4269/ajtmh.20-0467. Epub 2020 Jun 16.

Emergence of Undetectable Malaria Parasites: A Threat under the Radar amid the COVID-19 Pandemic?

Khalid B Beshir  1 , Lynn Grignard  1 , Khalid Hajissa  2 , Abdulrahman Mohammed  3 , Awolkhier M Nurhussein  4 , Deus S Ishengoma  5 , Inke Nadia D Lubis  6 , Chris J Drakeley  1 , Colin J Sutherland  1
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Emergence of Undetectable Malaria Parasites: A Threat under the Radar amid the COVID-19 Pandemic?

Khalid B Beshir et al. Am J Trop Med Hyg. 2020 Aug.

Abstract

Rapid diagnostic tests (RDTs) play a critical role in malaria diagnosis and control. The emergence of Plasmodium falciparum parasites that can evade detection by RDTs threatens control and elimination efforts. These parasites lack or have altered genes encoding histidine-rich proteins (HRPs) 2 and 3, the antigens recognized by HRP2-based RDTs. Surveillance of such parasites is dependent on identifying false-negative RDT results among suspected malaria cases, a task made more challenging during the current pandemic because of the overlap of symptoms between malaria and COVID-19, particularly in areas of low malaria transmission. Here, we share our perspective on the emergence of P. falciparum parasites lacking HRP2 and HRP3, and the surveillance needed to identify them amid the COVID-19 pandemic.

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References

    1. Mahase E, 2020. China coronavirus: WHO declares international emergency as death toll exceeds 200. BMJ 368: m408. - PubMed
    1. World Health Organization , 2019. World Malaria Report 2019. Geneva, Switzerland: WHO.
    1. World Health Organization , 2020. The Potential Impact of Health Service Disruptions on the Burden of Malaria: a Modelling Analysis for Countries in Sub-saharan Africa. Geneva, Switzerland: WHO; Licence: CC BY-NC-SA 3.0 IGO.
    1. World Health Organization , 2015. Malaria Rapid Diagnostic Test Performance: Results of WHO Product Testing of Malaria RDTs: Round 6 (2014–2015). Geneva, Switzerland: WHO.
    1. World Health Organization , 2017. False-negative RDT Results and Implications of New Reports of P. falciparum Histidine-Rich Protein 2/3 Gene Deletions. Geneva, Switzerland: WHO.

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