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Review
. 2020 Jun 17;106(6):899-911.
doi: 10.1016/j.neuron.2020.05.031.

Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging

Ukrae H Cho  1 , Martin W Hetzer  2
Affiliations
Review

Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging

Ukrae H Cho et al. Neuron. .

Abstract

In recent years, the nuclear pore complex (NPC) has emerged as a key player in genome regulation and cellular homeostasis. New discoveries have revealed that the NPC has multiple cellular functions besides mediating the molecular exchange between the nucleus and the cytoplasm. In this review, we discuss non-transport aspects of the NPC focusing on the NPC-genome interaction, the extreme longevity of the NPC proteins, and NPC dysfunction in age-related diseases. The examples summarized herein demonstrate that the NPC, which first evolved to enable the biochemical communication between the nucleus and the cytoplasm, now doubles as the gatekeeper of cellular identity and aging.

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Figures

Figure 1.
Figure 1.. NPC in gene regulation and aging.
(A) Nups can regulate genes both at and away from the NPC, typically by recruiting transcription factors, chromatin remodelers, RNA helicases, or other auxiliary proteins. They can either activate or suppress genes. (B) The NPC can be compromised by various mechanisms during aging.
Figure 2.
Figure 2.. NPC stoichiometry and Nup expression vary in different cell types and tissues.
(A) A p-value heatmap that visualizes the differential expression of Nups in HEK293 and four different human cancer cell lines. A low p-value means that Nup protein level in a given cell line significantly differs from that in others. Image reproduced from (Ori et al., 2013) under a Creative Commons license (https://creativecommons.org/licenses/by/4.0/). (B) Nup mRNA (Uhlen et al., 2015) and (C) protein expression (Kim et al., 2014) in various cells and tissues.
See this image and copyright information in PMC

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