In Vitro and Animal Models for SARS-CoV-2 research

doi:10.1016/j.tips.2020.05.005

Review

. 2020 Aug;41(8):513-517.

doi: 10.1016/j.tips.2020.05.005. Epub 2020 May 30.

In Vitro and Animal Models for SARS-CoV-2 research

Kazuo Takayama¹

Affiliations

PMID: 32553545
PMCID: PMC7260555
DOI: 10.1016/j.tips.2020.05.005

Review

In Vitro and Animal Models for SARS-CoV-2 research

Kazuo Takayama. Trends Pharmacol Sci. 2020 Aug.

. 2020 Aug;41(8):513-517.

doi: 10.1016/j.tips.2020.05.005. Epub 2020 May 30.

Author

Kazuo Takayama¹

Affiliation

¹ Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan. Electronic address: kazuo.takayama@cira.kyoto-u.ac.jp.

PMID: 32553545
PMCID: PMC7260555
DOI: 10.1016/j.tips.2020.05.005

Abstract

Basic research on SARS-CoV-2 is essential to understand its detailed pathophysiology and identify best drug targets. Models that can faithfully reproduce the viral life cycle and reproduce the pathology of COVID-19 are required. Here, we briefly review the cell lines, organoids, and animal models that are currently being used in COVID-19 research.

Keywords: COVID-19; SARS-CoV-2; animal models; cell models; organoids.

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Figures

**Figure 1**
Schematic Showing a Decision Flowchart of Cell Lines, Organoids, and Animal Models in Studying COVID-19 Pathophysiology. Figure created with Biorender (https://biorender.com).

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References

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1. Li Q. Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia. N. Engl. J. Med. 2020;382:1199–1207. - PMC - PubMed
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1. Zhu N. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 2020;382:727–733. - PMC - PubMed

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[1] Lu H. Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle. J. Med. Virol. 2020;92:401–402. - PMC - PubMed

[2] Lu H. Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle. J. Med. Virol. 2020;92:401–402. - PMC - PubMed

[3] Li Q. Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia. N. Engl. J. Med. 2020;382:1199–1207. - PMC - PubMed

[4] Li Q. Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia. N. Engl. J. Med. 2020;382:1199–1207. - PMC - PubMed

[5] Lythgoe M.P., Middleton P. Ongoing clinical trials for the management of the COVID-19 pandemic. Trends Pharmacol. Sci. 2020;41:363–382. - PMC - PubMed

[6] Lythgoe M.P., Middleton P. Ongoing clinical trials for the management of the COVID-19 pandemic. Trends Pharmacol. Sci. 2020;41:363–382. - PMC - PubMed

[7] Hoffmann M. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181:271–280. - PMC - PubMed

[8] Hoffmann M. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181:271–280. - PMC - PubMed

[9] Zhu N. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 2020;382:727–733. - PMC - PubMed

[10] Zhu N. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 2020;382:727–733. - PMC - PubMed

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In Vitro and Animal Models for SARS-CoV-2 research

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In Vitro and Animal Models for SARS-CoV-2 research

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