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Review
. 2020 Aug;41(8):513-517.
doi: 10.1016/j.tips.2020.05.005. Epub 2020 May 30.

In Vitro and Animal Models for SARS-CoV-2 research

Kazuo Takayama  1
Affiliations
Review

In Vitro and Animal Models for SARS-CoV-2 research

Kazuo Takayama. Trends Pharmacol Sci. 2020 Aug.

Abstract

Basic research on SARS-CoV-2 is essential to understand its detailed pathophysiology and identify best drug targets. Models that can faithfully reproduce the viral life cycle and reproduce the pathology of COVID-19 are required. Here, we briefly review the cell lines, organoids, and animal models that are currently being used in COVID-19 research.

Keywords: COVID-19; SARS-CoV-2; animal models; cell models; organoids.

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Figures

Figure 1
Figure 1
Schematic Showing a Decision Flowchart of Cell Lines, Organoids, and Animal Models in Studying COVID-19 Pathophysiology. Figure created with Biorender (https://biorender.com).
See this image and copyright information in PMC

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