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. 2020 Sep;41(3):353-356.
doi: 10.1016/j.rbmo.2020.04.025. Epub 2020 May 8.

Generating translatable evidence to improve patient care: the contribution of human factors

Affiliations

Generating translatable evidence to improve patient care: the contribution of human factors

Masoud A M Afnan et al. Reprod Biomed Online. 2020 Sep.

Abstract

Generating translatable evidence to improve patient care has proved challenging in reproductive medicine, with many 'add-on' treatments in routine assisted conception clinical practice that have not been reliably tested. This has consequences for patient care; specifically, IVF pregnancy rates have not improved. A change of culture is required in our profession, from indiscriminately applying the latest 'add-on' to large-scale participation in generating reliable translatable evidence.

Keywords: Big data; Human factors; RCT; Translational evidence.

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References

    1. Bik, E., 2020. Thoughts on the Gautret et al. paper about Hydroxychloroquine and Azithromycin treatment of COVID-19 infections [WWW Document]. Sci. Integr. Dig. URLhttps://scienceintegritydigest.com/2020/03/24/thoughts-on-the-gautret-et... (accessed 4.9.20).
    1. Chalmers I., Glasziou P. Avoidable waste in the production and reporting of research evidence. Lancet (London, England) 2009;374:86–89. doi: 10.1016/S0140–6736(09)60329–9. https://doi.org/ - DOI - PubMed
    1. Chen Z.J., Shi Y., Sun Y., Zhang B., Liang X., Cao Y., Yang J., Liu J., Wei D., Weng N., Tian L., Hao C., Yang D., Zhou F., Shi J., Xu Y., Li J., Yan J., Qin Y., Zhao H., Zhang H., Legro R.S. Fresh versus frozen embryos for infertility in the polycystic ovary syndrome. N. Engl. J. Med. 2016;375:523–533. doi: 10.1056/NEJMoa1513873. https://doi.org/ - DOI - PubMed
    1. Collins R., Bowman L., Landray M., Peto R. The Magic of Randomization versus the Myth of Real-World Evidence. N. Engl. J. Med. 2020;382:674–678. - PubMed
    1. Coomarasamy, A., Devall, A.J., Brosens, J.J., Quenby, S., Stephenson, M.D., Sierra, S., Christiansen, O.B., Small, R., Brewin, J., Roberts, T.E., Dhillon-Smith, R., Harb, H., Noordali, H., Papadopoulou, A., Eapen, A., Prior, M., Carlo Di Renzo, G., Hinshaw, K., Mol, B.W., Ann Lumsden, M., Khalaf, Y., Shennan, A., Goddijn, M., van Wely, M., Al-Memar, M., Bennett, P., Bourne, T., Rai, R., Regan, L., Gallos, I.D., Tommy, F., 2019a. Micronized vaginal progesterone to prevent miscarriage: a critical evaluation of randomized evidence. https://doi.org/ 10.1016/j.ajog.2019.12.006 - PMC - PubMed