doi: 10.1007/BF01025247.
The regions of alpha-neurotoxin binding on the extracellular part of the alpha-subunit of human acetylcholine receptor
Affiliations
- PMID: 3255368
- DOI: 10.1007/BF01025247
Item in Clipboard
The regions of alpha-neurotoxin binding on the extracellular part of the alpha-subunit of human acetylcholine receptor
J Protein Chem.
1988 Apr.
Abstract
A set of 18 synthetic uniform overlapping peptides spanning the entire extracellular part (residues 1-210) of the alpha-subunit of human acetylcholine receptor were studied for their binding activity of 125I-labeled alpha-bungarotoxin and cobratoxin. A major toxin-binding region was found to reside within peptide alpha 122-138. In addition, low-binding activities were obtained with peptides alpha 34-49 and alpha 194-210. It is concluded that the region within residues alpha 122-138 constitutes a universal major toxin-binding region for acetylcholine receptor of various species.
Similar articles
-
The short-neurotoxin-binding regions on the alpha-chain of human and Torpedo californica acetylcholine receptors.Biochem J. 1991 Mar 15;274 ( Pt 3)(Pt 3):849-54. doi: 10.1042/bj2740849. Biochem J. 1991. PMID: 2012611 Free PMC article.
-
Profile of the alpha-bungarotoxin-binding regions on the extracellular part of the alpha-chain of Torpedo californica acetylcholine receptor.Biochem J. 1987 Dec 15;248(3):847-52. doi: 10.1042/bj2480847. Biochem J. 1987. PMID: 3435488 Free PMC article.
-
Synthetic peptides corresponding to sequences of snake venom neurotoxins and rabies virus glycoprotein bind to the nicotinic acetylcholine receptor.Proteins. 1987;2(4):298-307. doi: 10.1002/prot.340020406. Proteins. 1987. PMID: 3448605
-
Molecular recognition of acetylcholine receptor. Recognition by alpha-neurotoxins and by immune and autoimmune responses and manipulation of the responses.Adv Neuroimmunol. 1994;4(4):403-32. doi: 10.1016/0960-5428(94)00037-o. Adv Neuroimmunol. 1994. PMID: 7536603 Review. No abstract available.
-
Localization of the functional sites on the alpha chain of acetylcholine receptor.Fed Proc. 1987 Jun;46(8):2538-47. Fed Proc. 1987. PMID: 2439384 Review.
Cited by
-
Localization and synthesis of an insulin-binding region on human insulin receptor.J Protein Chem. 1990 Apr;9(2):229-33. doi: 10.1007/BF01025313. J Protein Chem. 1990. PMID: 2201312
-
The short-neurotoxin-binding regions on the alpha-chain of human and Torpedo californica acetylcholine receptors.Biochem J. 1991 Mar 15;274 ( Pt 3)(Pt 3):849-54. doi: 10.1042/bj2740849. Biochem J. 1991. PMID: 2012611 Free PMC article.
-
Seventh International Conference on Methods in Protein Sequence Analysis. July 3-8, 1988, West Berlin, F.R.G. Short communications.J Protein Chem. 1988 Jun;7(3):187-324. J Protein Chem. 1988. PMID: 3250582 No abstract available.
-
Analysis of exposed regions on the main extracellular domain of mouse acetylcholine receptor alpha subunit in live muscle cells by binding profiles of antipeptide antibodies.J Protein Chem. 1994 Nov;13(8):715-22. doi: 10.1007/BF01886954. J Protein Chem. 1994. PMID: 7710661
-
10th International Conference on Methods in Protein Structure Analysis. September 8-13, 1994, Snowbird, Utah. Short communications and abstracts.J Protein Chem. 1994 Jul;13(5):431-543. J Protein Chem. 1994. PMID: 7945799 No abstract available.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources