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Multicenter Study
. 2021 May 1;43(4):e564-e566.
doi: 10.1097/MPH.0000000000001848.

Asymptomatic Right Atrial Thrombosis After Acute Lymphoblastic Leukemia Treatment

Kirsten B Jarvis  1   2   3 , Nadine G Andersson  4 , Mia Giertz  5   6 , Liisa Järvelä  7   8 , Olle Lindinger  9 , Satu Långström  10 , Riitta Niinimäki  11   12 , Sauli Palmu  13   14 , Sonata S Trakymiene  15   16 , Ruta Tuckuviene  17 , Kaisa Vepsäläinen  18 , Susanna Ranta  19   20 , Tony Frisk  19   20
Affiliations
Multicenter Study

Asymptomatic Right Atrial Thrombosis After Acute Lymphoblastic Leukemia Treatment

Kirsten B Jarvis et al. J Pediatr Hematol Oncol. .

Abstract

Right atrial thrombosis is a rare, but potentially serious complication of acute lymphoblastic leukemia treatment. We conducted a retrospective multicenter study to assess the incidence, treatment, and outcome of asymptomatic right atrial thrombosis detected at routine echocardiography of children after acute lymphoblastic leukemia treatment in the Nordic and Baltic countries. Eleven (2.7%, 95% confidence interval, 1.4-4.9) of 406 patients had asymptomatic right atrial thrombosis, ranging from 10 to 25 mm at detection. Three patients were treated with anticoagulation. None of the thromboses affected cardiac function, and they showed neither sign of progress nor spontaneous or treatment-related regress at follow-up.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Korones DN, Buzzard CJ, Asselin BL, et al. Right atrial thrombi in children with cancer and indwelling catheters. J Pediatr. 1996;128:841–846.
    1. Pui CH, Pei D, Campana D, et al. A revised definition for cure of childhood acute lymphoblastic leukemia. Leukemia. 2014;28:2336–2343.
    1. Schmiegelow K, Forestier E, Hellebostad M, et al. Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia. Leukemia. 2010;24:345–354.
    1. Caruso V, Iacoviello L, Di Castelnuovo A, et al. Thrombotic complications in childhood acute lymphoblastic leukemia: a meta-analysis of 17 prospective studies comprising 1752 pediatric patients. Blood. 2006;108:2216–2222.
    1. Levy-Mendelovich S, Barg AA, Kenet G. Thrombosis in pediatric patients with leukemia. Thromb Res . 2018;164(suppl 1):S94–S97.

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