Review

. 2020 Aug;20(8):455-456.

doi: 10.1038/s41577-020-0373-7.

Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?

Shen-Ying Zhang^{1

2

3}, Qian Zhang^{4

5

6}, Jean-Laurent Casanova^{7

8

9

10

11}, Helen C Su¹²; COVID Team

Collaborators, Affiliations

Collaborators

COVID Team:
Laurent Abel, Paul Bastard, Aurélie Cobat, Emmanuelle Jouanguy, Luigi Notarangelo

Affiliations

¹ St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. shzh289@rockefeller.edu.
² Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France. shzh289@rockefeller.edu.
³ University of Paris, Imagine Institute, Paris, France. shzh289@rockefeller.edu.
⁴ St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. qzhang02@rockefeller.edu.
⁵ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France. qzhang02@rockefeller.edu.
⁶ University of Paris, Imagine Institute, Paris, France. qzhang02@rockefeller.edu.
⁷ St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. casanova@rockefeller.edu.
⁸ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France. casanova@rockefeller.edu.
⁹ University of Paris, Imagine Institute, Paris, France. casanova@rockefeller.edu.
¹⁰ Howard Hughes Medical Institute, New York, NY, USA. casanova@rockefeller.edu.
¹¹ Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France. casanova@rockefeller.edu.
¹² Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

PMID: 32555547
PMCID: PMC7302118
DOI: 10.1038/s41577-020-0373-7

Review

Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?

Shen-Ying Zhang et al. Nat Rev Immunol. 2020 Aug.

. 2020 Aug;20(8):455-456.

doi: 10.1038/s41577-020-0373-7.

Authors

Shen-Ying Zhang^{1

2

3}, Qian Zhang^{4

5

6}, Jean-Laurent Casanova^{7

8

9

10

11}, Helen C Su¹²; COVID Team

Collaborators

COVID Team:
Laurent Abel, Paul Bastard, Aurélie Cobat, Emmanuelle Jouanguy, Luigi Notarangelo

Affiliations

¹ St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. shzh289@rockefeller.edu.
² Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France. shzh289@rockefeller.edu.
³ University of Paris, Imagine Institute, Paris, France. shzh289@rockefeller.edu.
⁴ St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. qzhang02@rockefeller.edu.
⁵ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France. qzhang02@rockefeller.edu.
⁶ University of Paris, Imagine Institute, Paris, France. qzhang02@rockefeller.edu.
⁷ St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. casanova@rockefeller.edu.
⁸ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France. casanova@rockefeller.edu.
⁹ University of Paris, Imagine Institute, Paris, France. casanova@rockefeller.edu.
¹⁰ Howard Hughes Medical Institute, New York, NY, USA. casanova@rockefeller.edu.
¹¹ Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France. casanova@rockefeller.edu.
¹² Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

PMID: 32555547
PMCID: PMC7302118
DOI: 10.1038/s41577-020-0373-7

Abstract

Severe COVID-19 is rare in previously healthy individuals who are less than 50 years of age, affecting probably no more than 1 in 1,000 such infected individuals. We suggest that these patients may become critically ill because of monogenic inborn errors that disrupt protective immunity to SARS-CoV-2.

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Conflict of interest statement

The authors declare no competing interests.

References

1. Casanova J-L, Abel L. The human genetic determinism of life-threatening infectious diseases: genetic heterogeneity and physiological homogeneity? Hum. Genet. 2020;139:681–694. doi: 10.1007/s00439-020-02184-w. - DOI - PMC - PubMed
1. Wang TT, et al. IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity. Science. 2017;355:395–398. doi: 10.1126/science.aai8128. - DOI - PMC - PubMed
1. Zhang S-Y, et al. Human inborn errors of immunity to infection affecting cells other than leukocytes: from the immune system to the whole organism. Curr. Opin. Immunol. 2019;59:88–100. doi: 10.1016/j.coi.2019.03.008. - DOI - PMC - PubMed
1. Zhang Y, Su HC, Lenardo MJ. Genomics is rapidly advancing precision medicine for immunological disorders. Nat. Immunol. 2015;16:1001–1004. doi: 10.1038/ni.3275. - DOI - PubMed
1. Bousfiha A, et al. Human inborn errors of immunity: 2019 update of the IUIS Phenotypical Classification. J. Clin. Immunol. 2020;40:66–81. doi: 10.1007/s10875-020-00758-x. - DOI - PMC - PubMed

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Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?

Collaborators

Affiliations

Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Miscellaneous