Renal Manifestations in Children with Dengue Fever Hospitalized in Pediatric Intensive Care Unit

Abstract

Objective: To study the pattern of acute kidney injury in children with dengue infection hospitalized in an intensive care unit.

Methods: This is a retrospective study from January 2019 through December 2019. Various renal manifestations of dengue were studied and compared between the severity of dengue fever.

Results: Three hundred nineteen children with dengue fever were hospitalized and 127 needed intensive care admission. Among the 127 patients, 26 (20.5%) children developed acute kidney injury (AKI). Children with severe dengue developed a higher number of AKI (n = 20; 28.6%), as compared to dengue with warning sign group (n = 6; 11.8%). Colloid infusion, inotropic support, ventilatory requirement and presence of secondary hemophagocytic lymphohistiocytosis were the risk factors for AKI. Nine children underwent dialysis. Among the AKI group, 23 recovered and 3 died and all three had multi organ dysfunction syndrome.

Conclusions: It is essential to recognize the various renal manifestations of dengue AKI which is associated with increased mortality and morbidity.

Keywords: Acute kidney injury; Dengue fever; Dialysis; Severe dengue.