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Review
. 2020 Oct;39(10):1821-1830.
doi: 10.1007/s10096-020-03948-y. Epub 2020 Jun 17.

Virulence of Helicobacter pylori outer membrane proteins: an updated review

Chenjing Xu  1 , Djaleel Muhammad Soyfoo  2 , Yao Wu  1 , Shunfu Xu  3   4
Affiliations
Review

Virulence of Helicobacter pylori outer membrane proteins: an updated review

Chenjing Xu et al. Eur J Clin Microbiol Infect Dis. 2020 Oct.

Abstract

Helicobacter pylori (H. pylori) infection is associated with some gastric diseases, such as gastritis, peptic ulcer, and gastric cancer. CagA and VacA are known virulence factors of H. pylori, which play a vital role in severe clinical outcomes. Additionally, the expression of outer membrane proteins (OMPs) helps H. pylori attach to gastric epithelial cells at the primary stage and increases the virulence of H. pylori. In this review, we have summarized the paralogs of H. pylori OMPs, their genomic loci, and the different receptors of OMPs identified so far. We focused on five OMPs, BabA (HopS), SabA (HopP), OipA (HopH), HopQ, and HopZ, and one family of OMPs: Hom. We highlight the coexpression of OMPs with other virulence factors and their relationship with clinical outcomes. In conclusion, OMPs are closely related to the pathogenic processes of adhesion, colonization, persistent infection, and severe clinical consequences. They are potential targets for the prevention and treatment of H. pylori-related diseases.

Keywords: Helicobacter pylori; Outer membrane proteins; Virulence factors.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
BabA, SabA, and HopQ bind to respective receptors on mucous layer while the receptors of OipA, HopZ, and Hom remain to be determined. These OMPs promote the adhesion of H. pylori to host cells
See this image and copyright information in PMC

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