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. 2020 Oct;109(10):1948-1955.
doi: 10.1111/apa.15422. Epub 2020 Jul 6.

Novel coronavirus infection (COVID-19) in children younger than one year: A systematic review of symptoms, management and outcomes

Ali Ahmed Raba  1   2 , Anis Abobaker  3 , Ismail Suliman Elgenaidi  4 , Ahmed Daoud  5
Affiliations

Novel coronavirus infection (COVID-19) in children younger than one year: A systematic review of symptoms, management and outcomes

Ali Ahmed Raba et al. Acta Paediatr. 2020 Oct.

Abstract

Aim: The aim of this systematic review was to evaluate the clinical characteristics of COVID-19 in neonates and children under one year of age.

Methods: A systematic literature review of the MEDLINE, PubMed, CINAHL, Embase and EBSCO databases was carried out for studies from January 1, 2020, to April 7, 2020. We included all papers that addressed clinical manifestations, laboratory results, imaging findings and outcomes in infants and neonates.

Results: Our search identified 77 peer-reviewed papers, and 18 papers covering 160 infants were reviewed. One paper was from Vietnam, and the other 17 were from China: eight were cross-sectional studies, eight were case reports, one was a case series, and one was a prospective cohort study. The most common clinical symptoms were fever (54%) and cough (33%). Most infants were treated symptomatically, with frequent use of various empirical medications. Infants and neonates tended to have more severe COVID-19 disease than older children: 11 (7%) were admitted to intensive care and one infant died. The mortality rate was 0.006%, with favourable outcomes in most cases.

Conclusion: Infants and neonates were more vulnerable to more severe COVID-19 disease than older children, but morbidity and mortality were low.

Keywords: clinical characteristics; infants; neonates; novel coronavirus; outcomes.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

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FIGURE 1
FIGURE 1
PRISMA flow diagram showing study selection process
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References

    1. Coronavirus Disease (COVID‐19) – events as they happen [Internet]. Available from: https://www.who.int/emergencies/diseases/novel‐coronavirus‐2019/events‐a.... Accessed April 4, 2020
    1. CDC . Coronavirus Disease 2019 (COVID‐19) [Internet]. Centers for Disease Control and Prevention. 2020. Available from: https://www.cdc.gov/coronavirus/2019‐ncov/daily‐life‐coping/children.html. Accessed April 4, 2020
    1. Ludvigsson JF. Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020;109(6):1088‐1095. - PMC - PubMed
    1. Dong Y, Mo X, Hu Y, et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics. 2020;145(6):1–10. 10.1542/peds.2020-07025 - DOI
    1. Nathan N, Prevost B, Corvol H. Atypical presentation of COVID‐19 in young infants. Lancet. 2020;395(10235):1481. - PMC - PubMed

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