Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Oct;35(10):1863-1868.
doi: 10.1002/mds.28129. Epub 2020 Jun 17.

Subclinical Cardiac Microdamage, Motor Severity, and Cognition in Parkinson's Disease

Chi-Un Choe  1 , Louisa Niemann  1 , Catrin Englisch  1 , Elina Petersen  2 , Carsten Buhmann  1 , Monika Pötter-Nerger  1 , Stefan Blankenberg  3   4 , Christian Gerloff  1 , Edzard Schwedhelm  4   5 , Tanja Zeller  3   4
Affiliations

Subclinical Cardiac Microdamage, Motor Severity, and Cognition in Parkinson's Disease

Chi-Un Choe et al. Mov Disord. 2020 Oct.

Abstract

Background: We assessed if cardiac blood markers are associated with motor and cognitive function in patients with Parkinson's disease (PD).

Methods: High-sensitivity troponin I and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were evaluated in 285 PD patients. Furthermore, N-terminal pro-B-type natriuretic peptide levels were analyzed in 570 age, sex and cardiovascular risk factor matched healthy controls. Motor (UPDRS, Hoehn &Yahr) and cognitive function (Montreal Cognitive Assessemtn) were assessed at baseline in all 285 patients and after 1 year in 101 patients.

Results: N-terminal pro-B-type natriuretic peptide were significantly increased in 285 PD patients compared with 570 matched healthy controls. In PD patients, increased high-sensitivity troponin I and N-terminal pro-B-type natriuretic peptide levels were associated with worse motor function at baseline and also with motor decline after 1 year. N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I were inversely associated with cognitive function at baseline only in unadjusted models.

Conclusions: Subclinical cardiac microdamage is associated with motor severity in PD patients. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Keywords: Montreal cognitive assessment; N-terminal pro-B-type natriuretic peptide; high-sensitivity troponin I.

PubMed Disclaimer

Comment in

References

    1. Giannoccaro MP, La Morgia C, Rizzo G, Carelli V. Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease. Mov Disord 2017;32(3):346-363.
    1. Lang AE, Espay AJ. Disease modification in Parkinson's disease: current approaches, challenges, and future considerations. Mov Disord 2018;33(5):660-677.
    1. Murphy E, Ardehali H, Balaban RS, et al. Mitochondrial function, biology, and role in disease: a scientific statement from the American Heart Association. Circ Res 2016;118(12):1960-1991.
    1. Piqueras-Flores J, Lopez-Garcia A, Moreno-Reig A, et al. Structural and functional alterations of the heart in Parkinson's disease. Neurol Res 2018;40(1):53-61.
    1. Zesiewicz TA, Strom JA, Borenstein AR, et al. Heart failure in Parkinson's disease: analysis of the United States medicare current beneficiary survey. Parkinsonism Relat Disord 2004;10(7):417-420.

Publication types