Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2020 Sep;35(9):1626-1635.
doi: 10.1002/mds.28119. Epub 2020 Jun 18.

Meta-Analysis of Gut Dysbiosis in Parkinson's Disease

Hiroshi Nishiwaki  1 , Mikako Ito  1 , Tomohiro Ishida  2 , Tomonari Hamaguchi  1 , Tetsuya Maeda  3 , Kenichi Kashihara  4 , Yoshio Tsuboi  5 , Jun Ueyama  2 , Teppei Shimamura  6 , Hiroshi Mori  7 , Ken Kurokawa  7 , Masahisa Katsuno  8 , Masaaki Hirayama  2 , Kinji Ohno  1
Affiliations
Meta-Analysis

Meta-Analysis of Gut Dysbiosis in Parkinson's Disease

Hiroshi Nishiwaki et al. Mov Disord. 2020 Sep.

Abstract

Background: PD may begin with the intestinal accumulation of α-synuclein fibrils, which can be causally associated with gut dysbiosis. The variability of gut microbiota across countries prevented us from identifying shared gut dysbiosis in PD.

Objectives: To identify gut dysbiosis in PD across countries.

Methods: We performed 16S ribosomal RNA gene sequencing analysis of gut microbiota in 223 patients with PD and 137 controls, and meta-analyzed gut dysbiosis by combining our dataset with four previously reported data sets from the United States, Finland, Russia, and Germany. We excluded uncommon taxa from our analyses. For pathway analysis, we developed the Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis method.

Results: After adjusting for confounding factors (body mass index, constipation, sex, age, and catechol-O-methyl transferase inhibitor), genera Akkermansia and Catabacter, as well as families Akkermansiaceae, were increased, whereas genera Roseburia, Faecalibacterium, and Lachnospiraceae ND3007 group were decreased in PD. Catechol-O-methyl transferase inhibitor intake markedly increased family Lactobacillaceae. Inspection of these bacteria in 12 datasets that were not included in the meta-analysis revealed that increased genus Akkermansia and decreased genera Roseburia and Faecalibacterium were frequently observed across countries. Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis revealed changes in short-chain fatty acid metabolisms in our dataset.

Conclusions: We report that intestinal mucin layer-degrading Akkermansia is increased and that short-chain fatty acid-producing Roseburia and Faecalibacterium are decreased in PD across countries. © 2020 International Parkinson and Movement Disorder Society.

Keywords: Parkinson's disease; confounding factors; gut microbiota; meta-analysis; pathway analysis.

PubMed Disclaimer

References

    1. Bloch A, Probst A, Bissig H, Adams H, Tolnay M. Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neuropathol Appl Neurobiol 2006;32:284-295.
    1. Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003;24:197-211.
    1. Chiang HL, Lin CH. Altered gut microbiome and intestinal pathology in Parkinson's disease. J Mov Disord 2019;12:67-83.
    1. Gibbons CH, Garcia J, Wang N, Shih LC, Freeman R. The diagnostic discrimination of cutaneous alpha-synuclein deposition in Parkinson disease. Neurology 2016;87:505-512.
    1. Cersosimo MG, Benarroch EE. Pathological correlates of gastrointestinal dysfunction in Parkinson's disease. Neurobiol Dis 2012;46:559-564.

Publication types

Substances