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. 2020 Nov 10;9(5):523-529.
doi: 10.1093/jpids/piaa074.

The Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2 in a Pediatric Healthcare Network in the United States

William R Otto  1 , Sarah Geoghegan  1   2 , Leila C Posch  1 , Louis M Bell  1   3   4 , Susan E Coffin  1   4 , Julia S Sammons  1   4 , Rebecca M Harris  5 , Audrey R Odom John  1   4 , Xianqun Luan  6 , Jeffrey S Gerber  1   3   4
Affiliations

The Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2 in a Pediatric Healthcare Network in the United States

William R Otto et al. J Pediatric Infect Dis Soc. .

Abstract

Background: Understanding the prevalence and clinical presentation of coronavirus disease 2019 in pediatric patients can help healthcare providers and systems prepare and respond to this emerging pandemic.

Methods: This was a retrospective case series of patients tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) across a pediatric healthcare network, including clinical features and outcomes of those with positive test results.

Results: Of 7256 unique children tested for SARS-CoV-2, 424 (5.8%) tested positive. Patients aged 18-21 years had the highest test positive rate (11.2%), while those aged 1-5 years had the lowest (3.9%). By race, 10.6% (226/2132) of black children tested positive vs 3.3% (117/3592) of white children. By indication for testing, 21.1% (371/1756) of patients with reported exposures or clinical symptoms tested positive vs 3.8% (53/1410) of those undergoing preprocedural or preadmission testing. Of 424 patients who tested positive for SARS-CoV-2, 182 (42.9%) had no comorbidities, 87 (20.5%) had asthma, and 55 (13.0%) were obese. Overall, 52.1% had cough, 51.2% fever, and 14.6% shortness of breath. Seventy-seven (18.2%) SARS-CoV-2-positive patients were hospitalized, of whom 24 (31.2%) required respiratory support. SARS-CoV-2-targeted antiviral therapy was given to 9 patients, and immunomodulatory therapy to 18 patients. Twelve (2.8%) SARS-CoV-2-positive patients required mechanical ventilation, and 2 patients required extracorporeal membrane oxygenation. Two patients died.

Conclusions: In this large cohort of pediatric patients tested for SARS-CoV-2, the rate of infection was low but varied by testing indication. The majority of cases were mild and few children had critical illness.

Keywords: COVID-19; coronavirus; epidemiology; testing.

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Figures

Figure 1.
Figure 1.
Flow chart of the study population.
Figure 2.
Figure 2.
Severe acute respiratory syndrome coronavirus 2 testing experience at the Children’s Hospital of Philadelphia during the study period 9 March 2020 through 1 June 2020.
See this image and copyright information in PMC

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