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Review
. 2020 Jun 18;78(6):1055-1069.
doi: 10.1016/j.molcel.2020.04.017.

Ca2+ Fluxes and Cancer

Saverio Marchi  1 , Carlotta Giorgi  2 , Lorenzo Galluzzi  3 , Paolo Pinton  4
Affiliations
Review

Ca2+ Fluxes and Cancer

Saverio Marchi et al. Mol Cell. .

Abstract

Ca2+ ions are key second messengers in both excitable and non-excitable cells. Owing to the rather pleiotropic nature of Ca2+ transporters and other Ca2+-binding proteins, however, Ca2+ signaling has attracted limited attention as a potential target of anticancer therapy. Here, we discuss cancer-associated alterations of Ca2+ fluxes at specific organelles as we identify novel candidates for the development of drugs that selectively target Ca2+ signaling in malignant cells.

Keywords: IP(3)R; MCU complex; ORAI; TRP channels; mitochondrial permeability transition; store-operated calcium entry.

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Conflict of interest statement

Declaration of Interests L.G. received consulting fees from OmniSEQ, Astra Zeneca, Inzen, and the Luke Heller TECPR2 Foundation, and he is member of the Scientific Advisory Committee of Boehringer Ingelheim, The Longevity Labs, and OmniSEQ.

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