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. 2020 Jun 18;78(6):996-998.
doi: 10.1016/j.molcel.2020.05.027.

It's Not What You Say But How You Say It: Targeting RNA Methylation in AML

Sarah Naomi Olsen  1 , Scott A Armstrong  2
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It's Not What You Say But How You Say It: Targeting RNA Methylation in AML

Sarah Naomi Olsen et al. Mol Cell. .
Free article

Abstract

In this month's issue of Cancer Cell, Su et al. (2020) describe two small-molecule inhibitors of the RNA demethylase FTO that demonstrate significant anti-tumor effects in various models of acute myeloid leukemia.

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  • Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.
    Su R, Dong L, Li Y, Gao M, Han L, Wunderlich M, Deng X, Li H, Huang Y, Gao L, Li C, Zhao Z, Robinson S, Tan B, Qing Y, Qin X, Prince E, Xie J, Qin H, Li W, Shen C, Sun J, Kulkarni P, Weng H, Huang H, Chen Z, Zhang B, Wu X, Olsen MJ, Müschen M, Marcucci G, Salgia R, Li L, Fathi AT, Li Z, Mulloy JC, Wei M, Horne D, Chen J. Su R, et al. Cancer Cell. 2020 Jul 13;38(1):79-96.e11. doi: 10.1016/j.ccell.2020.04.017. Epub 2020 Jun 11. Cancer Cell. 2020. PMID: 32531268 Free PMC article.

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