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. 2020 Jun 18;27(6):635-637.
doi: 10.1016/j.chembiol.2020.05.011.

Fusicoccin Keeps Getting Stickier: Modulation of an Adaptor Protein Interactome with a Molecular Glue Leads to Neurite Outgrowth

Claire S Harmange Magnani  1 , Thomas J Maimone  2
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Fusicoccin Keeps Getting Stickier: Modulation of an Adaptor Protein Interactome with a Molecular Glue Leads to Neurite Outgrowth

Claire S Harmange Magnani et al. Cell Chem Biol. .
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Abstract

Many traditional drugs inhibit enzyme function; in contrast, some naturally "sticky" small molecules can stabilize protein-protein interactions. In this issue of Cell Chemical Biology, Kaplan et al. (2020) explore regulation of the 14-3-3 interactome by a small-molecule molecular glue leading to neurite outgrowth through a polypharmacological mechanism.

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