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Comment
. 2020 Sep;36(9):634-637.
doi: 10.1016/j.tig.2020.06.001. Epub 2020 Jun 16.

Demystifying Cancer Etiology via 3D Genome Mapping

Yuliang Feng  1 , Siim Pauklin  2
Affiliations
Comment

Demystifying Cancer Etiology via 3D Genome Mapping

Yuliang Feng et al. Trends Genet. 2020 Sep.

Abstract

Ramanand et al. perform the first high-resolution 3D genome mapping via ChIA-PET to capture RNAPII-associated chromatin interactions in normal prostate epithelial and prostate cancer cells. They describe how genetics, epigenetics, and the 3D genome architecture are coordinated in the aberrant gene expression that drives prostate cancer development.

Keywords: 3D genome organization; chromatin architecture; prostate cancer.

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  • The landscape of RNA polymerase II-associated chromatin interactions in prostate cancer.
    Ramanand SG, Chen Y, Yuan J, Daescu K, Lambros MB, Houlahan KE, Carreira S, Yuan W, Baek G, Sharp A, Paschalis A, Kanchwala M, Gao Y, Aslam A, Safdar N, Zhan X, Raj GV, Xing C, Boutros PC, de Bono J, Zhang MQ, Mani RS. Ramanand SG, et al. J Clin Invest. 2020 Aug 3;130(8):3987-4005. doi: 10.1172/JCI134260. J Clin Invest. 2020. PMID: 32343676 Free PMC article.

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