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. 2020 Sep;30(9):672-675.
doi: 10.1016/j.tcb.2020.05.004. Epub 2020 Jun 16.

Endoplasmic Reticulum (ER) Stress Response Failure in Diseases

Kashi Raj Bhattarai  1 , Manoj Chaudhary  1 , Hyung-Ryong Kim  2 , Han-Jung Chae  3
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Free article

Endoplasmic Reticulum (ER) Stress Response Failure in Diseases

Kashi Raj Bhattarai et al. Trends Cell Biol. 2020 Sep.
Free article

Abstract

Recent work provides evidence for the new terminology, 'endoplasmic reticulum (ER) stress response or sensing failure', in relation to metabolic disease. We seek to identify and amass possible conditions of ER stress response failure in various metabolic and age-related pathogenesis, including obesity and diabetes.

Keywords: ER proteostasis; ER stress; ER stress response failure; aging; metabolic diseases; sXBP1.

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