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Review
. 2020 Jun 19;147(12):dev175059.
doi: 10.1242/dev.175059.

The lateral plate mesoderm

Karin D Prummel  1   2 , Susan Nieuwenhuize  1   2 , Christian Mosimann  3   2
Affiliations
Review

The lateral plate mesoderm

Karin D Prummel et al. Development. .

Abstract

The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the developing vertebrate embryo. Despite this central role in development and evolution, the LPM remains challenging to study and to delineate, owing to its lineage complexity and lack of a concise genetic definition. Here, we outline the processes that govern LPM specification, organization, its cell fates and the inferred evolutionary trajectories of LPM-derived tissues. Finally, we discuss the development of seemingly disparate organ systems that share a common LPM origin.

Keywords: Cardiovascular system; Cell fate; Development; Evolution; Gene regulation; Lateral plate mesoderm.

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Conflict of interest statement

Competing interestsThe authors declare no competing or financial interests.

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