Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Feb;37(2):e3370.
doi: 10.1002/dmrr.3370. Epub 2020 Jul 18.

Chinese visceral adiposity index: A reliable indicator of visceral fat function associated with risk of type 2 diabetes

Minghui Han  1 , Pei Qin  1 , Quanman Li  2   3   4 , Ranran Qie  1   2 , Leilei Liu  2 , Yang Zhao  1   2 , Dechen Liu  1   2 , Dongdong Zhang  1   2 , Chunmei Guo  2 , Qionggui Zhou  1 , Gang Tian  2 , Shengbing Huang  2 , Xiaoyan Wu  1 , Yang Li  1 , Xingjin Yang  2 , Yang Zhao  2 , Yifei Feng  2 , Yu Liu  3 , Honghui Li  3 , Xizhuo Sun  3 , Qing Chen  4 , Tieqiang Wang  5 , Xiaoliang Chen  5 , Dongsheng Hu  1   2   3   4   5 , Ming Zhang  1
Affiliations

Chinese visceral adiposity index: A reliable indicator of visceral fat function associated with risk of type 2 diabetes

Minghui Han et al. Diabetes Metab Res Rev. 2021 Feb.

Abstract

Background: The evidence of the association between Chinese visceral adiposity index (CVAI) and risk of type 2 diabetes mellitus (T2DM) is limited. We explored the association of CVAI with T2DM and directly compared with the predictive power of CVAI with other visceral obesity indices (visceral adiposity index, waist to height ratio, waist circumference and body mass index) based on a large prospective study.

Methods: We conducted a population-based study of 12 237 Chinese participants. Cox proportional-hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between CVAI and T2DM.

Results: During follow-up (median: 6.01 years), the incidence of T2DM was 3.29, 7.34, 12.37 and 23.72 per 1000 person-years for quartiles 1, 2, 3 and 4 of CVAI, respectively. The risk of T2DM was increased with quartiles 2, 3 and 4 vs quartile 1 of CVAI (HR 2.12 [95% CI 1.50-3.00], 2.94 [2.10-4.13] and 5.01 [3.57-7.04], Ptrend < 0.001). Per-SD increase in CVAI was associated with a 72% increased risk of T2DM (HR 1.72 [95% CI 1.56-1.88]). Sensitivity analyses did not alter the association. The area under receiver operating characteristic curve was significantly higher for CVAI than other visceral obesity indices (all P <.001). Similar results were observed in stratified analyses by sex.

Conclusions: Our findings show a positive association between CVAI and risk of T2DM. CVAI has the best performance in predicting incident T2DM, so the index might be a reliable and applicable indicator identifying people at high risk of T2DM.

Keywords: Chinese visceral adiposity index; prospective cohort study; receiver operating characteristic; type 2 diabetes mellitus.

PubMed Disclaimer

References

REFERENCES

    1. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet. 2016;387(10027):1513-1530.
    1. GBD 2017 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017. Lancet. 2018;392(10159):1859-1922.
    1. GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the global burden of disease study 2017. Lancet. 2018;392(10159):1736-1788.
    1. International Diabetic Federation. IDF Diabetes Atlas, 9th edition. https://diabetesatlas.org/en/. Accessed November 25, 2019.
    1. American Diabetes Association. Lifestyle management: standards of medical care in diabetes-2018. Diabetes Care. 2018;41(1):S38-S50.

Publication types

LinkOut - more resources