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Review
. 2020 Oct;17(10):e2000186.
doi: 10.1002/cbdv.202000186. Epub 2020 Sep 24.

Recent Advances on Marine Alkaloids from Sponges

Changhao Bian  1 , Jiangming Wang  1 , Xinyi Zhou  1 , Wenhui Wu  1   2   3 , Ruihua Guo  1   2   3
Affiliations
Review

Recent Advances on Marine Alkaloids from Sponges

Changhao Bian et al. Chem Biodivers. 2020 Oct.

Abstract

Alkaloids from marine secondary metabolites have received extensive attention from pharmacists in recent years. Miscellaneous alkaloids derived from marine sponges possessed various pharmacological activities including cytotoxicity, antimicrobial, antioxidant, and so on. Herein, we summarized 149 marine alkaloids from sponges based on their structures and bioactivities reported from 2015 to 2020 and analyzed the production environment of marine sponges with rich alkaloids. Moreover, we discussed biosynthesis routes of pyrrole and guanidine alkaloids from marine sponges Agelas and Monanchora. This article will be beneficial for future research on drugs from marine natural products.

Keywords: alkaloids; biological activity; carboline alkaloids; indole alkaloids; sponges.

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