Statins and other drugs: Facing COVID-19 as a vascular disease

Fabian Sanchis-Gomar¹, Carme Perez-Quilis², Emmanuel J Favaloro³, Giuseppe Lippi⁴

Affiliations

¹ Department of Physiology, Faculty of Medicine, University of Valencia and INCLIVA Biomedical Research Institute, Valencia, Spain. Electronic address: fabian.sanchis@uv.es.
² Department of Physiology, Faculty of Medicine, University of Valencia and INCLIVA Biomedical Research Institute, Valencia, Spain.
³ Haematology, Sydney Centers for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research (ICPMR), NSW Health Pathology, Westmead Hospital, Westmead, NSW, Australia.
⁴ Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.

PMID: 32562814
PMCID: PMC7834489
DOI: 10.1016/j.phrs.2020.105033

Comment

Statins and other drugs: Facing COVID-19 as a vascular disease

Fabian Sanchis-Gomar et al. Pharmacol Res. 2020 Sep.

. 2020 Sep:159:105033.

doi: 10.1016/j.phrs.2020.105033. Epub 2020 Jun 17.

Authors

Fabian Sanchis-Gomar¹, Carme Perez-Quilis², Emmanuel J Favaloro³, Giuseppe Lippi⁴

Affiliations

¹ Department of Physiology, Faculty of Medicine, University of Valencia and INCLIVA Biomedical Research Institute, Valencia, Spain. Electronic address: fabian.sanchis@uv.es.
² Department of Physiology, Faculty of Medicine, University of Valencia and INCLIVA Biomedical Research Institute, Valencia, Spain.
³ Haematology, Sydney Centers for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research (ICPMR), NSW Health Pathology, Westmead Hospital, Westmead, NSW, Australia.
⁴ Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.

PMID: 32562814
PMCID: PMC7834489
DOI: 10.1016/j.phrs.2020.105033

No abstract available

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Comment on

The Effects of ARBs, ACEis, and Statins on Clinical Outcomes of COVID-19 Infection Among Nursing Home Residents.
De Spiegeleer A, Bronselaer A, Teo JT, Byttebier G, De Tré G, Belmans L, Dobson R, Wynendaele E, Van De Wiele C, Vandaele F, Van Dijck D, Bean D, Fedson D, De Spiegeleer B. De Spiegeleer A, et al. J Am Med Dir Assoc. 2020 Jul;21(7):909-914.e2. doi: 10.1016/j.jamda.2020.06.018. Epub 2020 Jun 15. J Am Med Dir Assoc. 2020. PMID: 32674818 Free PMC article.

References

1. Ackermann M., Verleden S.E., Kuehnel M., Haverich A., Welte T., Laenger F., Vanstapel A., Werlein C., Stark H., Tzankov A., Li W.W., Li V.W., Mentzer S.J., Jonigk D. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N. Engl. J. Med. 2020 doi: 10.1056/NEJMoa2015432. - DOI - PMC - PubMed
1. Varga Z., Flammer A.J., Steiger P., Haberecker M., Andermatt R., Zinkernagel A.S., Mehra M.R., Schuepbach R.A., Ruschitzka F., Moch H. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395(10234):1417–1418. - PMC - PubMed
1. El Sabbagh A., Prasad M., Zack C.J., Widmer R.J., Karon B.S., Lerman A., Jaffe A.S. High-sensitivity troponin in patients with coronary artery endothelial dysfunction. J. Invasive Cardiol. 2018;30(11):406–410. - PubMed
1. Lippi G., Lavie C.J., Sanchis-Gomar F. Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): evidence from a meta-analysis. Prog. Cardiovasc. Dis. 2020 doi: 10.1016/j.pcad.2020.03.001. - DOI - PMC - PubMed
1. Bifulco M., Gazzerro P. Statins in coronavirus outbreak: it’s time for experimental and clinical studies. Pharmacol. Res. 2020;156 - PMC - PubMed

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Statins and other drugs: Facing COVID-19 as a vascular disease

Affiliations

Statins and other drugs: Facing COVID-19 as a vascular disease

Authors

Affiliations

Conflict of interest statement

Comment on

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical