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Review
. 2021 Jan:92:53-64.
doi: 10.1016/j.nucmedbio.2020.06.005. Epub 2020 Jun 12.

The emerging role of cell surface receptor and protein binding radiopharmaceuticals in cancer diagnostics and therapy

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Review

The emerging role of cell surface receptor and protein binding radiopharmaceuticals in cancer diagnostics and therapy

Luigi Aloj et al. Nucl Med Biol. 2021 Jan.

Abstract

Targeting specific cell membrane markers for both diagnostic imaging and radionuclide therapy is a rapidly evolving field in cancer research. Some of these applications have now found a role in routine clinical practice and have been shown to have a significant impact on patient management. Several molecular targets are being investigated in ongoing clinical trials and show promise for future implementation. Advancements in molecular biology have facilitated the identification of new cancer-specific targets for radiopharmaceutical development.

Keywords: Cell membrane proteins; Positron emission tomography; Radiopharmaceutical development; Receptors; Targeted radionuclide therapy.

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