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Review
. 2020 Jun;112(3):315-323.
doi: 10.1016/j.jnma.2020.05.018. Epub 2020 Jun 18.

Contemporary and Future Concepts on Hypertension in African Americans: COVID-19 and Beyond

Keith Ferdinand  1 , Tivona Batieste  2 , Mashli Fleurestil  2
Affiliations
Review

Contemporary and Future Concepts on Hypertension in African Americans: COVID-19 and Beyond

Keith Ferdinand et al. J Natl Med Assoc. 2020 Jun.

Abstract

Background: Cardiovascular disease related mortality is the leading cause of death in the United States, with hypertension being the most prevalent and potent risk factor. For decades hypertension has disproportionately affected African Americans, who also have a higher burden of associated comorbidities including diabetes and heart failure.

Methods: Current literature including guideline reports and newer studies on hypertension in African Americans in PubMed were reviewed. We also reviewed newer publications on the relationship between COVID-19 and cardiovascular disease.

Findings: While APOL1 has been theorized in the epidemiology of hypertension, the increased prevalence and associated risks are primarily due to environmental and lifestyle factors. These factors include poor diet, adverse lifestyle, and social determinants. Hypertension control can be achieved by lifestyle modifications such as low sodium diet, weight loss, and adequate physical activity. When lifestyle modifications alone do not adequately control hypertension, a common occurrence among African Americans who suffer with greater prevalence of resistant hypertension, pharmacological intervention is indicated. The efficacy of renal denervation, and the use of sodium-glucose cotransporter 2 and aminopeptidase A inhibitors, have been studied for treatment of resistant hypertension. Furthermore, the recent COVID-19 crisis has been particularly devastating among African Americans who demonstrate increased incidence and poorer health outcomes related to the disease.

Conclusion: The disparities in outcomes, which are largely attributable to a greater prevalence of comorbidities such as hypertension and obesity, in addition to adverse environmental and socioeconomic factors, highlight the necessity of specialized clinical approaches and programs for African Americans to address longstanding barriers to equitable care.

Keywords: African Americans; COVID-19; Hypertension.

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Figures

Figure 1
Figure 1
Life expectancy at birth, by race and sex: United States, 1970–2017. Source: CDC.gov
Figure 2
Figure 2
Factors affecting HTN/CVD morbidity and mortality.
Figure 3
Figure 3
Future directions in HTN and CVD risk control. SMBP-Self monitoring blood pressure. HTN-Hypertension. CVD-Cardiovascular disease. SGLT2-Sodium glucose cotransporter 2.
See this image and copyright information in PMC

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