"Dysmorphic" lysosomes in proximal tubular cells are not specific for CINAC/CKDu and do not provide evidence that CINAC/CKDu is a toxin-induced disease

Affiliations

¹ Department of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, Stockholm, Sweden.
² Department of Laboratory Medicine, Division of Clinical Research Centre, Karolinska Institutet, Stockholm, Sweden.
³ Cardiovascular, Renal and Metabolism Safety, Clinical Pharmacology and Safety Sciences, AstraZeneca R&D, Gothenburg, Sweden; Clinical Pathology/Cytology Department, Karolinska University Hospital, Stockholm, Sweden.
⁴ Department of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, Stockholm, Sweden; Clinical Pathology/Cytology Department, Karolinska University Hospital, Stockholm, Sweden. Electronic address: annika.wernerson@ki.se.

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Julia Wijkström et al. Kidney Int. 2020 Sep.

Free article

. 2020 Sep;98(3):786-787.

doi: 10.1016/j.kint.2020.04.057. Epub 2020 Jun 18.

¹ Department of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, Stockholm, Sweden.
² Department of Laboratory Medicine, Division of Clinical Research Centre, Karolinska Institutet, Stockholm, Sweden.
³ Cardiovascular, Renal and Metabolism Safety, Clinical Pharmacology and Safety Sciences, AstraZeneca R&D, Gothenburg, Sweden; Clinical Pathology/Cytology Department, Karolinska University Hospital, Stockholm, Sweden.
⁴ Department of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, Stockholm, Sweden; Clinical Pathology/Cytology Department, Karolinska University Hospital, Stockholm, Sweden. Electronic address: annika.wernerson@ki.se.

No abstract available

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The authors reply.
Vervaet BA, Nast CC, Schreurs G, Jayasumana C, Herath C, De Broe ME. Vervaet BA, et al. Kidney Int. 2020 Sep;98(3):787-789. doi: 10.1016/j.kint.2020.06.021. Epub 2020 Jul 2. Kidney Int. 2020. PMID: 32622832 No abstract available.

Chronic interstitial nephritis in agricultural communities is a toxin-induced proximal tubular nephropathy.
Vervaet BA, Nast CC, Jayasumana C, Schreurs G, Roels F, Herath C, Kojc N, Samaee V, Rodrigo S, Gowrishankar S, Mousson C, Dassanayake R, Orantes CM, Vuiblet V, Rigothier C, D'Haese PC, De Broe ME. Vervaet BA, et al. Kidney Int. 2020 Feb;97(2):350-369. doi: 10.1016/j.kint.2019.11.009. Epub 2019 Nov 23. Kidney Int. 2020. PMID: 31892415