Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun;80(6):588-600.
doi: 10.1055/a-1139-9380. Epub 2020 Jun 17.

ABC5 International Consensus Conference on Advanced Breast Cancer, Lisbon, 16 November 2019: Commentary by the German panel of experts on the ABC5 voting results

Michael Untch  1 , Rachel Würstlein  2 , Diana Lüftner  3 , Renate Haidinger  4 , Peter A Fasching  5 , Doris Augustin  6 , Susanne Briest  7 , Johannes Ettl  8 , Frank Förster  9 , Christian M Kurbacher  10 , Hans-Joachim Lück  11 , Norbert Marschner  12 , Lothar Müller  13 , Volkmar Müller  14 , Isabel Radke  15 , Eugen Ruckhäberle  16 , Iris Scheffen  17 , Eva Schumacher-Wulf  18 , Moritz Schwoerer  19 , Dieter Steinfeld-Birg  20 , Katja Ziegler-Löhr  21 , Christoph Thomssen  22 , Nadia Harbeck  23
Affiliations

ABC5 International Consensus Conference on Advanced Breast Cancer, Lisbon, 16 November 2019: Commentary by the German panel of experts on the ABC5 voting results

Michael Untch et al. Geburtshilfe Frauenheilkd. 2020 Jun.

Abstract

The Advanced Breast Cancer Fifth International Consensus Conference (ABC5) which focuses on the diagnosis and treatment of advanced breast cancer was held in Lisbon on November 14 - 16, 2019. The aim of the conference is to standardize the treatment of advanced breast cancer worldwide using evidence-based data and to ensure that patients with advanced breast disease anywhere in the world are treated appropriately and have access to the latest therapies. This year, the emphasis was on new developments and study results from patients with advanced breast cancer as well as precision medicine. The collaboration with patient advocates from all over the globe is also an important goal of the ABC Conference, which is why the international ABC panel also included a number of patient advocates. We present a commentary on the voting results of the ABC5 panelists in Lisbon by a working group of German breast cancer specialists together with the implications for routine clinical care in Germany. The commentary is based on the recommendations of the Breast Commission of the German Gynecological Oncology Working Group (AGO). This commentary is useful, it includes country-specific features for the ABC consensus.

Keywords: 2019 study data; ABC5 consensus; advanced breast cancer; precision medicine.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest/Interessenkonflikt Prof. Michael Untch: honoraria paid to his employer (for adboard participation, presentations) and travel grants from Amgen, AstraZeneca, BMS, Celgene, Daiichi Sankyo, Eisai, Janssen Cilag, Johnson & Johnson, Lilly Deutschland, Lilly International, MSD Merck, Mundipharma, Myriad Genetics, Odonate, Pfizer, PUMA Biotechnology, Riemser, Roche, Sanofi Aventis, Sividon Diagnostics, Teva Pharmaceuticals Ind. Ltd. PD Dr. med. Rachel Würstlein received honoraria from Agendia, Amgen, AstraZeneca, Boehringer Ingelheim, Carl Zeiss, Celgene, Daiichi Sankyo, Eisai, Genomic Health, GSK, Lilly, MSD, Mundipharma, NanoString, Novartis, Odonate, Paxman, Palleos, Pfizer, Pierre Fabre, Puma Biotechnology, Riemser, Roche, Sandoz/Hexal, Seattle Genetics, Tesaro Bio, Teva. Prof. Diana Lüftner received honoraria from Amgen, AstraZeneca, Celgene, Daiichi Sankyo, Esai, Genomic Health, GSK, Lilly, MSD, Mundipharma, Novartis, Pfizer, Pierre Fabre, Puma Biotechnology, Riemser, Roche, Tesaro Bio, Teva. Renate Haidinger has no conflict of interest. Prof. Peter A. Fasching received honoraria from Roche, Pfizer, Celgene, Daiichi Sankyo, Merck Sharp & Dohme, Myelo Therapeutics, Eisai, Puma, Lilly, Novartis, AstraZeneca, and his institution received research funding from BionTech and Cepheid. Prof. Christoph Thomssen received honoraria from Amgen, AstraZeneca, Celgene, Daiichi Sankyo, Eisai, Lilly, MSD, Mundipharma, MEDA, Novartis, Roche, Tesaro, Vifor. Prof. Nadia Harbeck received honoraria for lectures and/or consultancy work from Amgen, AstraZeneca, BMS, Celgene, Daiichi Sankyo, Lilly, MSD, Novartis, Odonate, Pierre Fabre, Pfizer, Roche, Sandoz/Hexal, Seattle Genetics. Dr. med. Doris Augustin has no conflict of interest. Dr. med. Susanne Briest has no conflict of interest. Dr. med. Johannes Ettl received honoraria from AstraZeneca, Roche, Celgene, Novartis, Lilly, Pfizer, Pierre Fabre, Teva and travel grants from Celgene, Lily, Novartis, Pfizer, Teva, Pierre Fabre. Prof. Frank Förster received honoraria from Roche, Novartis, AstraZeneca, Eisai, Lilly, Pfizer, Tesaro, MSD, Celgene. Dr. med. Christian Kurbacher received honoraria from Amgen, Axios, Eli Lilly, Hilotherm, Mundipharma, NewCo, Novartis, Pfizer, Riemser, Roche, Tesaro. Research funding from AstraZeneca, Axios, MSD Sharp & Dohme, NewCo, Novartis, Pfizer, PharmaMar, Riemser, Seattle Genetics. Honoraria from Amgen, Eli Lilly, Novartis, Mundipharma, Pfizer, PharmaMar, Riemser, Roche, Tesaro; travel grants and other expenses from Amgen, Hexal, Pfizer, PharmaMar, Tesaro, Teva Oncology. Prof. Hans-Joachim Lück has no conflict of interest. Dr. med. Norbert Marschner received speakerʼs fees from Lilly, Roche, Novartis, Clovis, GSK, Amgen, Mylan, Eisai, Mundipharma, Novella, SEAGEN, and travel grants from Lilly, Roche. Dr. med. Lothar Müller received travel grants from octapharm and Medac. Prof. Volkmar Müller received honoraria from Amgen, AstraZeneca, Celgene, Daiichi-Sankyo, Eisai, Pfizer, MSD, Novartis, Roche, Teva, and honoraria for consultancy work from Genomic Health, Hexal, Roche, Pierre Fabre, Amgen, ClinSol, Novartis, MSD, Daiichi-Sankyo, Eisai, Lilly, Tesaro, Nektar. Dr. med. Isabel Radke received honoraria and/or travel grants from Amgen, AstraZeneca, Celgene, Genomic Health, Novartis, Pierre Fabre, Pfizer, Roche, Teva. Prof. Eugen Ruckhäberle received honoraria from Amgen, AstraZeneca, Pharma Mar, Celgene, Daiichi Sankyo, Eisai, GSK, Lilly, MSD, Novartis, Pfizer, Pierre Fabre, Riemser, Roche, Sandoz/Hexal, Seattle Genetics, Tesaro Bio, Clovis Oncology, Teva. Dr. med. Iris Scheffen received honoraria from Amgen, Celgene, MSD, Novartis, Pfizer, Roche. Eva Schumacher-Wulf has no conflict of interest. Dr. med. Moritz Schwoerer received honoraria for adboard participation from Roche. Dr. med. Dieter Steinfeld-Birg received honoraria from Amgen, Hexal, Roche, Teva, Novartis. Dr. med. Katja Ziegler-Löhr received honoraria from Celgene, Novartis, Oncovis, Roche, Tesaro./ Prof. Michael Untch: Honorare an den Arbeitgeber (für Adboard-Teilnahme, Präsentationen) und Reiseunterstützung von Amgen, AstraZeneca, BMS, Celgene, Daiichi Sankyo, Eisai, Janssen Cilag, Johnson & Johnson, Lilly Deutschland, Lilly International, MSD Merck, Mundipharma, Myriad Genetics, Odonate, Pfizer, PUMA Biotechnology, Riemser, Roche, Sanofi Aventis, Sividon Diagnostics, Teva Pharmaceuticals Ind. Ltd. PD Dr. med. Rachel Würstlein erhielt Honorar von Agendia, Amgen, AstraZeneca, Boehringer Ingelheim, Carl Zeiss, Celgene, Daiichi Sankyo, Eisai, Genomic Health, GSK, Lilly, MSD, Mundipharma, NanoString, Novartis, Odonate, Paxman, Palleos, Pfizer, Pierre Fabre, Puma Biotechnology, Riemser, Roche, Sandoz/Hexal, Seattle Genetics, Tesaro Bio, Teva. Prof. Diana Lüftner erhielt Honorar von Amgen, AstraZeneca, Celgene, Daiichi Sankyo, Esai, Genomic Health, GSK, Lilly, MSD, Mundipharma, Novartis, Pfizer, Pierre Fabre, Puma Biotechnology, Riemser, Roche, Tesaro Bio, Teva. Renate Haidinger hat keinen Interessenkonflikt. Prof. Peter A. Fasching erhielt Honorare von Roche, Pfizer, Celgene, Daiichi Sankyo, Merck Sharp & Dohme, Myelo Therapeutics, Eisai, Puma, Lilly, Novartis, AstraZeneca und seine Institution erhielt Forschungsunterstützung von BionTech und Cepheid. Prof. Christoph Thomssen erhielt Honorar von Amgen, AstraZeneca, Celgene, Daiichi Sankyo, Eisai, Lilly, MSD, Mundipharma, MEDA, Novartis, Roche, Tesaro, Vifor. Prof. Nadia Harbeck erhielt Honorare für Vorträge und/oder Beratung von Amgen, AstraZeneca, BMS, Celgene, Daiichi Sankyo, Lilly, MSD, Novartis, Odonate, Pierre Fabre, Pfizer, Roche, Sandoz/Hexal, Seattle Genetics. Dr. med. Doris Augustin hat keinen Interessenkonflikt. Dr. med. Susanne Briest hat keinen Interessenkonflikt. Dr. med. Johannes Ettl erhielt Honorar von AstraZeneca, Roche, Celgene, Novartis, Lilly, Pfizer, Pierre Fabre, Teva und Reiseunterstützung von Celgene, Lily, Novartis, Pfizer, Teva, Pierre Fabre. Prof. Frank Förster erhielt Honorar von Roche, Novartis, AstraZeneca, Eisai, Lilly, Pfizer, Tesaro, MSD, Celgene. Dr. med. Christian Kurbacher erhielt Honorar von Amgen, Axios, Eli Lilly, Hilotherm, Mundipharma, NewCo, Novartis, Pfizer, Riemser, Roche, Tesaro. Forschungsunterstützung von AstraZeneca, Axios, MSD Sharp & Dohme, NewCo, Novartis, Pfizer, PharmaMar, Riemser, Seattle Genetics. Honorare von Amgen, Eli Lilly, Novartis, Mundipharma, Pfizer, PharmaMar, Riemser, Roche, Tesaro; Reiseunterstützung und sonstige Ausgaben von Amgen, Hexal, Pfizer, PharmaMar, Tesaro, Teva Oncology. Prof. Hans-Joachim Lück hat keinen Interessenkonflikt. Dr. med. Norbert Marschner erhielt Vortragshonorare von Lilly, Roche, Novartis, Clovis, GSK, Amgen, Mylan, Eisai, Mundipharma, Novella, SEAGEN und Reisekostenerstattung von Lilly, Roche. Dr. med. Lothar Müller erhielt Reiseunterstützung von octapharm und Medac. Prof. Volkmar Müller erhielt Honorar von Amgen, AstraZeneca, Celgene, Daiichi-Sankyo, Eisai, Pfizer, MSD, Novartis, Roche, Teva, und Beratungshonorar von Genomic Health, Hexal, Roche, Pierre Fabre, Amgen, ClinSol, Novartis, MSD, Daiichi-Sankyo, Eisai, Lilly, Tesaro, Nektar. Dr. med. Isabel Radke erhielt Honorar und/oder Reiseunterstützung von Amgen, AstraZeneca, Celgene, Genomic Health, Novartis, Pierre Fabre, Pfizer, Roche, Teva. Prof. Eugen Ruckhäberle erhielt Honorar von Amgen, AstraZeneca, Pharma Mar, Celgene, Daiichi Sankyo, Eisai, GSK, Lilly, MSD, Novartis, Pfizer, Pierre Fabre, Riemser, Roche, Sandoz/Hexal, Seattle Genetics, Tesaro Bio, Clovis Oncology, Teva. Dr. med. Iris Scheffen erhielt Honorar von Amgen, Celgene, MSD, Novartis, Pfizer, Roche. Eva Schumacher-Wulf hat keinen Interessenkonflikt. Dr. med. Moritz Schwoerer erhielt Honorar für Adboard-Teilnahme von Roche. Dr. med. Dieter Steinfeld-Birg erhielt Honorar von Amgen, Hexal, Roche, Teva, Novartis. Dr. med. Katja Ziegler-Löhr erhielt Honorar von Celgene, Novartis, Oncovis, Roche, Tesaro.

References

    1. AGO State-of-the-Art Empfehlungen Diagnose und Therapie des frühen und fortgeschrittenen Mammakarzinoms. Update 2020. Online (last access: 04.03.2020):www.ago-online.de
    1. Cardoso F, Senkus E, Costa A. ESO-ESMO 4th international consensus guidelines for advanced breast cancer (ABC 4) Ann Oncol. 2018;29:1634–1657. - PMC - PubMed
    1. Harbeck N, Lüftner D, Marschner N. ABC4 Consensus: Assessment by a German Group of Experts. Breast Care (Basel) 2018;13:48–58. - PMC - PubMed
    1. Cardoso F, Costa A, Norton L. 1st International consensus guidelines for advanced breast cancer (ABC 1) doi:10.1016/j.breast.2012.03.003. Breast. 2012;21:242–252. - PubMed
    1. Cardoso F, Costa A, Norton L. ESO-ESMO 2nd international consensus guidelines for advanced breast cancer (ABC2) Breast. 2014;23:489–502. - PubMed