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. 2020 Sep;8(3):423-433.
doi: 10.1002/iid3.324. Epub 2020 Jun 21.

Allergic symptoms and sensitisation in adolescents with cows' milk allergy and atopic eczema in infancy

Sonja Piippo  1 , Mirva Viljanen  1 , Erkki Savilahti  1 , Mikael Kuitunen  1
Affiliations

Allergic symptoms and sensitisation in adolescents with cows' milk allergy and atopic eczema in infancy

Sonja Piippo et al. Immun Inflamm Dis. 2020 Sep.

Abstract

Background: The association between atopic sensitisation, atopic eczema (AE) and asthma is known, but distinct roles of allergies on long-term health are unestablished.

Objective: Evaluation of allergic symptoms and sensitisation in adolescents who in infancy had AE and verified cows' milk allergy (CMA) or AE and a negative CMA challenge, and controls.

Methods: Children with AE, with and without CMA, from a randomised controlled study in 1999-2001 examining the effect of probiotics on AE severity at older than 12 months of age, attended a follow-up visit at age 16 to 18, with age-matched controls. Data came from a questionnaire (ISAAC questionnaire), analysis of serum antigen-specific immunoglobulin Es (IgEs), and clinical evaluation. Group comparisons were carried out (χ2 tests and logistic regression).

Results: Fifty-two patients with AE and CMA (AE/CMA+ group), 52 with AE and suspicion of CMA (AE/CMA- group), and 57 controls attended a study visit. IgE-mediated sensitisation was significantly more prevalent in the AE/CMA+ group vs the controls, for horse, cat, dog, egg white and wheat (P < .024 for all). For birch, timothy and mugwort (P < .008 for all), sensitisation was more prevalent in both the AE/CMA+ group and the AE/CMA- group vs controls. On the basis of questionnaire data the AE/CMA + group reported a significantly higher lifetime prevalence of wheezing (64% vs 35% and 32%; P = .001), noninfectious rhinitis (85% vs 62% and 56%; P = .004), and hay fever (77% vs 52% and 33%; P < .001) vs the AE/CMA- group and the control group, respectively.

Conclusion and clinical relevance: Patients with AE and CMA in infancy, as opposed to patients with AE only, or controls, report more allergic symptoms and exhibit more allergic sensitisation in adolescence. This indicates that CMA in infancy is an independent risk factor of allergic disease in adolescence.

Keywords: adolescent; allergic rhinitis; asthma; atopic eczema; cows' milk allergy; specific IgE.

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Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Flowchart of the study
See this image and copyright information in PMC

References

    1. Mastrorilli C, Caffarelli C, Hoffmann‐Sommergruber K. Food allergy and atopic dermatitis: prediction, progression, and prevention. Pediatr Allergy Immunol. 2017;28(8):831‐840. - PubMed
    1. Høst A, Halken S, Jacobsen HP, Christensen AE, Herskind AM, Plesner K. Clinical course of cow's milk protein allergy/intolerance and atopic diseases in childhood. Pediatr Allergy Immunol. 2002;13(s15):23‐28. - PubMed
    1. Schoemaker AA, Sprikkelman AB, Grimshaw KE, et al. Incidence and natural history of challenge‐proven cow's milk allergy in European children—EuroPrevall birth cohort. Allergy. 2015;70(8):963‐972. - PubMed
    1. Wood RA, Sicherer SH, Vickery BP, et al. The natural history of milk allergy in an observational cohort. J Allergy Clin Immunol. 2012;131(3):805‐812, e4. - PMC - PubMed
    1. Niggemann B, Beyer K. Diagnosis of food allergy in children: toward a standardization of food challenge. J Pediatr Gastroenterol Nutr. 2007;45(4):399‐404. - PubMed

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