Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep;353(9):e2000090.
doi: 10.1002/ardp.202000090. Epub 2020 Jun 22.

Synthesis and antidiabetic evaluation of benzimidazole-tethered 1,2,3-triazoles

Laxmi Deswal  1 , Vikas Verma  1 , Devinder Kumar  1 , Chander P Kaushik  1 , Ashwani Kumar  2 , Yogesh Deswal  1 , Suman Punia  1
Affiliations

Synthesis and antidiabetic evaluation of benzimidazole-tethered 1,2,3-triazoles

Laxmi Deswal et al. Arch Pharm (Weinheim). 2020 Sep.

Abstract

Some novel benzimidazole-tethered 1,2,3-triazole derivatives (4a-r) were synthesized by a click reaction between 2-substituted 1-(prop-2-yn-1-yl)-1H-benzo[d]imidazole and in situ azide. The structures of the synthesized compounds were confirmed by spectroscopic studies (one- and two-dimensional nuclear magnetic resonance, Fourier transform infrared, and high-resolution mass spectra). The synthesized compounds were evaluated for their antidiabetic activity. Compounds 4a-r exhibited a good-to-moderate α-amylase and α-glucosidase inhibitory activity, with IC50 values ranging from 0.0410 to 0.0916 µmol/ml and 0.0146 to 0.0732 µmol/ml, respectively. Compounds 4e, 4g, and 4n were found to be most active. Furthermore, the binding conformation of the most active compounds was ascertained by docking studies.

Keywords: 1,2,3-triazole; antidiabetic; benzimidazole; docking; α-amylase; α-glucosidase.

PubMed Disclaimer

References

REFERENCES

    1. P. Saeedi, I. Petersohn, P. Salpea, B. Malanda, S. Karuranga, N. Unwin, S. Colagiuri, L. Guariguata, A. A. Motala, K. Ogurtsova, J. E. Shaw, D. Bright, R. Williams; the IDF Diabetes Atlas Committee, Diabetes Res. Clin. Pract. 2019, 157, 107843.
    1. M. A. Ibrahim, N. A. Koorbanally, S. Islam, Acta Pharm. 2014, 64, 311.
    1. J. B. Xiao, P. Hogger, Curr. Med. Chem. 2015, 22, 23.
    1. C. M. Ma, M. Hattori, M. Daneshtalab, L. Wang, J. Med. Chem. 2008, 51, 6188.
    1. L. Zeng, G. Zhang, Y. Liao, D. Gong, Food Funct. 2016, 7, 3953.

MeSH terms

LinkOut - more resources