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. 2020 Jun 22;16(6):e1008570.
doi: 10.1371/journal.ppat.1008570. eCollection 2020 Jun.

Biological sex impacts COVID-19 outcomes

Sabra L Klein  1   2 , Santosh Dhakal  1 , Rebecca L Ursin  2 , Sharvari Deshpande  1 , Kathryn Sandberg  3 , Franck Mauvais-Jarvis  4   5
Affiliations

Biological sex impacts COVID-19 outcomes

Sabra L Klein et al. PLoS Pathog. .

Abstract

The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Sex-disaggregated numbers of COVID-19 cases, hospitalizations, and deaths per 100,000 people in NYC.
Data were accessed from https://www1.nyc.gov/site/doh/covid/covid-19-data.page on April 11, 2020. COVID-19, novel coronavirus disease 2019; NYC, New York City.
See this image and copyright information in PMC

References

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