Is Heterozygosity for the Alpha-1 Antitrypsin Risk Allele Pi∗MZ a Disease Modifier or Genetic Risk Factor?

Affiliations

¹ Christian Doppler Laboratory of Iron and Phosphate Biology; Department of Medicine I, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: heinz.zoller@i-med.ac.at.
² Christian Doppler Laboratory of Iron and Phosphate Biology; Department of Medicine I, Medical University of Innsbruck, Innsbruck, Austria.
³ Department of Medicine I, Medical University of Innsbruck, Innsbruck, Austria.

Editorial

Heinz Zoller et al. Gastroenterology. 2020 Aug.

. 2020 Aug;159(2):433-434.

doi: 10.1053/j.gastro.2020.06.035. Epub 2020 Jun 20.

¹ Christian Doppler Laboratory of Iron and Phosphate Biology; Department of Medicine I, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: heinz.zoller@i-med.ac.at.
² Christian Doppler Laboratory of Iron and Phosphate Biology; Department of Medicine I, Medical University of Innsbruck, Innsbruck, Austria.
³ Department of Medicine I, Medical University of Innsbruck, Innsbruck, Austria.

No abstract available

Comment on

Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi∗Z Variant of AAT (Pi∗MZ vs Pi∗ZZ genotype) and Noncarriers.
Schneider CV, Hamesch K, Gross A, Mandorfer M, Moeller LS, Pereira V, Pons M, Kuca P, Reichert MC, Benini F, Burbaum B, Voss J, Gutberlet M, Woditsch V, Lindhauer C, Fromme M, Kümpers J, Bewersdorf L, Schaefer B, Eslam M, Bals R, Janciauskiene S, Carvão J, Neureiter D, Zhou B, Wöran K, Bantel H, Geier A, Dirrichs T, Stickel F, Teumer A, Verbeek J, Nevens F, Govaere O, Krawczyk M, Roskams T, Haybaeck J, Lurje G, Chorostowska-Wynimko J, Genesca J, Reiberger T, Lammert F, Krag A, George J, Anstee QM, Trauner M, Datz C, Gaisa NT, Denk H, Trautwein C, Aigner E, Strnad P; European Alpha-1 Liver Study Group. Schneider CV, et al. Gastroenterology. 2020 Aug;159(2):534-548.e11. doi: 10.1053/j.gastro.2020.04.058. Epub 2020 May 4. Gastroenterology. 2020. PMID: 32376409