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Review
. 2020 Jun;29(3):150921.
doi: 10.1016/j.sempedsurg.2020.150921. Epub 2020 May 16.

Medullary Thyroid Carcinoma in Children

Claire E Graves  1 , Jessica E Gosnell  2
Affiliations
Review

Medullary Thyroid Carcinoma in Children

Claire E Graves et al. Semin Pediatr Surg. 2020 Jun.

Abstract

The vast majority of medullary thyroid carcinomas (MTC) in children are inherited as part of the multiple endocrine neoplasia (MEN) syndromes MEN2A and MEN2B, and the related variant, familial MTC. Prophylactic surgery in infants and children identified through genetic screening leads to the highest survival in these patients. This article summarizes the current recommendations for screening, treatment, and surveillance of children with MTC to provide a concise clinically relevant review for pediatric practitioners.

Keywords: MEN2; MEN2A; MEN2B; Medullary thyroid cancer; Medullary thyroid carcinoma; Multiple endocrine neoplasia syndrome; Pediatric cancer.

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