Pediatric parathyroid disease

Abstract

Parathyroid glands are critical for calcium and phosphate homeostasis. Parathyroid disease is relatively rare in the pediatric population, but there are some important pediatric-specific considerations and conditions. This article reviews parathyroid physiology, disorders of hyper- and hypo- function, operative management, and uniquely pediatric diagnoses such as neonatal severe hyperparathyroidism. Advances in preoperative imaging, intra-operative gland identification, and management of post-thyroidectomy hypocalcemia are also presented in detail. This article combines a review of fundamentals with recent advances in care, emphasizing pediatric-specific publications.

Keywords: Hyperparathyroidism; Hypoparathyroidism; Neonatal Severe Hyperparathyroidism; Parathyroid; Parathyroid Carcinoma; Parathyroid Imaging; Post-thyroidectomy Hypocalcemia.