Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep;21(9):491-493.
doi: 10.1038/s41580-020-0266-4.

Old and new models for the study of human ageing

Anne Brunet  1   2
Affiliations

Old and new models for the study of human ageing

Anne Brunet. Nat Rev Mol Cell Biol. 2020 Sep.

Abstract

Human ageing is associated with high susceptibility to disease. Some aspects of ageing can be studied directly in humans and have revealed that ageing is influenced by many factors, including genetics, lifestyle, sex and socio-economic status. But identifying the factors that cause and modulate the ageing process often requires experimental interventions and modelling that can only be performed in model systems.

PubMed Disclaimer

Conflict of interest statement

Competing interests

The author declares no competing interests.

References

    1. Guarente L & Kenyon C Genetic pathways that regulate ageing in model organisms. Nature 408, 255–262 (2000). - PubMed
    1. Piper MDW & Partridge L Drosophila as a model for ageing. Biochim. Biophys. Acta Mol. Basis Dis 1864, 2707–2717 (2018). - PubMed
    1. Mannick JB et al. TORC1 inhibition enhances immune function and reduces infections in the elderly. Sci. Transl Med 10, eaaq1564 (2018). - PubMed
    1. Mitchell SJ, Scheibye-Knudsen M, Longo DL & de Cabo R Animal models of aging research: implications for human aging and age-related diseases. Annu. Rev. Anim. Biosci 3, 283–303 (2015). - PubMed
    1. Cellerino A, Valenzano DR & Reichard M From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology. Biol. Rev. Camb. Philos. Soc 91, 511–533 (2016). - PubMed

Publication types