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Comment
. 2020 Sep;46(9):1779-1780.
doi: 10.1007/s00134-020-06150-y. Epub 2020 Jun 22.

Between-centre differences for COVID-19 ICU mortality from early data in England

Zhaozhi Qian  1 , Ahmed M Alaa  2 , Mihaela van der Schaar  1 , Ari Ercole  3
Affiliations
Comment

Between-centre differences for COVID-19 ICU mortality from early data in England

Zhaozhi Qian et al. Intensive Care Med. 2020 Sep.
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
a Fixed effects estimates for CHESS predictors and mean APACHE-II score for each site from national audit data. The strongest patient-factor predictors are older age, immunosuppressive disease and chronic heart/renal disease. The inset shows mortality probability over time for young, intermediate and older age groups. b Random effects showing between centres variation showing a hazard ratio variation between sites from 0 to over + 4 which is comparable in magnitude to the strongest CHESS predictor (older age) showing that between-centres variation is an appreciable determinant of outcome. 95% CIs shown
See this image and copyright information in PMC

Comment on

  • Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal.
    Wynants L, Van Calster B, Collins GS, Riley RD, Heinze G, Schuit E, Bonten MMJ, Dahly DL, Damen JAA, Debray TPA, de Jong VMT, De Vos M, Dhiman P, Haller MC, Harhay MO, Henckaerts L, Heus P, Kammer M, Kreuzberger N, Lohmann A, Luijken K, Ma J, Martin GP, McLernon DJ, Andaur Navarro CL, Reitsma JB, Sergeant JC, Shi C, Skoetz N, Smits LJM, Snell KIE, Sperrin M, Spijker R, Steyerberg EW, Takada T, Tzoulaki I, van Kuijk SMJ, van Bussel B, van der Horst ICC, van Royen FS, Verbakel JY, Wallisch C, Wilkinson J, Wolff R, Hooft L, Moons KGM, van Smeden M. Wynants L, et al. BMJ. 2020 Apr 7;369:m1328. doi: 10.1136/bmj.m1328. BMJ. 2020. Update in: BMJ. 2021 Feb 3;372:n236. doi: 10.1136/bmj.n236. PMID: 32265220 Free PMC article. Updated.

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