Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep;46(9):1781-1783.
doi: 10.1007/s00134-020-06157-5. Epub 2020 Jun 22.

SARS-CoV-2 viral loads and serum IgA/IgG immune responses in critically ill COVID-19 patients

Slim Fourati  1   2   3 , Sophie Hue  2   4   5   6 , Jean-Michel Pawlotsky  1   2   3 , Armand Mekontso-Dessap  2   7   8 , Nicolas de Prost  9   10   11   12
Affiliations

SARS-CoV-2 viral loads and serum IgA/IgG immune responses in critically ill COVID-19 patients

Slim Fourati et al. Intensive Care Med. 2020 Sep.
No abstract available

PubMed Disclaimer

Conflict of interest statement

SF, SH, AMD, and NDP have no conflict of interest to disclose. JMP has received research grants from Abbott, Abbvie, and Gilead; he has served as an advisor for Abbott, Abbvie, Gilead, Merck, and Siemens Healthcare.

Figures

Fig. 1
Fig. 1
a Correlation between the number of days since onset of symptoms and intensive care unit (ICU) admission and the serum titer of anti-S1 IgA, expressed in arbitrary units (AU) (Spearman’s r = 0.70; p < 0.001; r2 = 0.40); b correlation between the number of days since onset of symptoms of SARS-CoV-2 infection and ICU admission and the serum titer of anti-S1 IgG (AU) (Spearman’s r = 0.68; p < 0.001, r2 = 0.22); c correlation between the serum titer of anti-S1 IgA (AU) and the SARS-CoV-2 viral load measured in nasopharyngeal swabs (expressed in cycle threshold value, Ct) (Spearman’s r = 0.69; p < 0.001; r2 = 0.35); d correlation between the serum titer of anti-S1 IgG (AU) and the SARS-CoV-2 viral load measured in nasopharyngeal swabs (expressed in Ct) (Spearman’s r = 0.72; p < 0.0001; r2 = 0.29); note that the x-axis of c, d is inverted so as to reflect that the RT-PCR Ct is inversely correlated with RNA viral load; e comparisons of serum anti-S1 IgA titers obtained upon ICU admission between patients who were alive at day-28 of ICU admission and patients who died; f comparisons of serum anti-S1 IgG titers obtained upon ICU admission between patients who were alive at day 28 of ICU admission and patients who died; continuous lines represent the lines of best fit of the linear regressions and the dotted lines show their 95% confidence intervals; horizontal lines represent the median value; p values displayed in e, f come from the Mann–Whitney test
See this image and copyright information in PMC

References

    1. Phua J, Weng L, Ling L, Egi M, Lim CM, Divatia JV, Shrestha BR, Arabi YM, Ng J, Gomersall CD, Nishimura M, Koh Y, Du B. Intensive care management of coronavirus disease 2020 (COVID-19): challenges and recommendations. Lancet Respir Med. 2020;8(5):506–517. doi: 10.1016/S2213-2600(20)30161-2. - DOI - PMC - PubMed
    1. Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, Huang H, Zhang L, Du C, Zhang Y, Song J, Wang S, Chao Y, Yang Z, Xu J, Chen D, Xiong W, Xu L, Zhou F, Jiang J, Bai C, Zheng J, Song Y. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 2020 doi: 10.1001/jamainternmed.2020.0994. - DOI - PMC - PubMed
    1. Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, Cereda D, Coluccello A, Foti G, Fumagalli R, Iotti G, Latronico N, Lorini L, Merler S, Natalini G, Piatti A, Ranieri MV, Scandroglio AM, Storti E, Cecconi M, Pesenti A. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020;323(16):1574–1581. doi: 10.1001/jama.2020.5394. - DOI - PMC - PubMed
    1. Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, Wu Y, Zhang L, Yu Z, Fang M, Yu T, Wang Y, Pan S, Zou X, Yuan S, Shang Y. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020;8(5):475–481. doi: 10.1016/S2213-2600(20)30079-5. - DOI - PMC - PubMed

MeSH terms

LinkOut - more resources