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Observational Study
. 2021 Feb;88(2):134-140.
doi: 10.1007/s12098-020-03355-3. Epub 2020 Jun 23.

Surface TREM-1 as a Prognostic Biomarker in Pediatric Sepsis

Semra Şen  1 , Fulya Kamit  2 , Rana İşgüder  3 , Pınar Yazıcı  4 , Zümrüt Şahbudak Bal  5 , İlker Devrim  6 , S Nuri Bayram  6 , Bülent Karapınar  4 , Ayşe Berna Anıl  2 , Fadıl Vardar  5
Affiliations
Observational Study

Surface TREM-1 as a Prognostic Biomarker in Pediatric Sepsis

Semra Şen et al. Indian J Pediatr. 2021 Feb.

Abstract

Objectives: To investigate the association between the triggering receptor expressed on myeloid cells-1 (TREM-1) levels and prognosis in septic children.

Methods: Patients admitted to pediatric intensive care units (PICU) of three tertiary centers were included in this prospective observational study. Serum samples were taken at admission from patients who were hospitalized with sepsis.

Results: Of the 87 patients included, 34 (39.1%) had severe sepsis and 53 (60.9%) had septic shock. The median age was 2 y (2 mo to 16 y). TREM-1 values were found to be significantly higher in septic shock patients 129 pg/ml (min 9.85- max 494.90) compared to severe sepsis 105 pg/ml (min 8.21- max 289.17) (p = 0.048). Despite higher TREM-1 levels been measured in non-survivors compared to survivors, it was not statistically significant [168.98 pg/ml (min 9.85- max 494.90) vs. 110.79 pg/ml (min 8.21- max 408.90), (p = 0.075)].

Conclusions: Admission TREM-1 levels were higher in septic shock compared to severe sepsis patients. There was no association between mortality and TREM-1 levels in sepsis. TREM-1 measurements should be used carefully in pediatric sepsis prognosis.

Keywords: Child; Mortality; Prognosis; Sepsis; Severe sepsis; Shock; TREM-1.

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