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Randomized Controlled Trial
. 2021 Mar;27(3):177-182.
doi: 10.1007/s11655-020-3266-5. Epub 2020 Jun 22.

Essential Oil from Citrus aurantium Alleviates Anxiety of Patients Undergoing Coronary Angiography: A Single-Blind, Randomized Controlled Trial

Khalil Moradi  1 , Hossein Ashtarian  2 , Nicholas Yakubu Danzima  3 , Hamid Saeedi  4 , Behrouz Bijan  1 , Farzaneh Akbari  1 , Mohammad Mehdi Mohammadi  5
Affiliations
Randomized Controlled Trial

Essential Oil from Citrus aurantium Alleviates Anxiety of Patients Undergoing Coronary Angiography: A Single-Blind, Randomized Controlled Trial

Khalil Moradi et al. Chin J Integr Med. 2021 Mar.

Abstract

Objective: To determine the effectiveness and safety of essential oil from Citrus aurantium on anxiety in patients undergoing coronary angiography.

Methods: A single-blind, randomized controlled trial was conducted in 80 patients experiencing coronary angiography in Imam Ali Hospital in Kermanshah, Iran from April to November in 2016. All patients were randomly divided into intervention and control groups by a random number table, 40 cases in each group. The patients in the intervention group inhaled Citrus aurantium essential oil for 15-20 min about 60 min before angiography. Following the same procedure, distilled water was used instead of Citrus aurantium in the control group. Spielbergers State-Trait Anxiety Inventory (STAI) was filled in and vital signs including systolic blood pressure (SBP), diastolic blood pressure (DBP), respiratory and pulse rate were recorded before and 20 min after the intervention. Adverse reactions after intervention were observed.

Results: In the intervention group, the mean scores of STAI, SBP, DBP, respiratory and pulse rate were 53.30 ± 10.13, 134.82 ± 11.75 mm Hg, 84.49 ± 6.99 mm Hg, 17.87 ± 1.73 times/min, and 76.48 ± 12.55 beats/min at baseline and significantly decreased to 42.37 ± 10.15, 124.49 ± 10.48 mm Hg, 79.23 ± 6.62 mm Hg, 14.54 ± 1.43 times/min, and 70.03 ± 13.66 beats/min respectively 20 min after intervention (all P<0.05); however, in the control group, neither anxiety scores nor vital signs changed significantly (P>0.05). All subjects reported no adverse reactions.

Conclusion: Inhalation of the essential oil from Citrus aurantium was effective in reducing anxiety and stress levels in patients undergoing coronary angiography.

Trial registration: IRCT2016040816797N2 (retrospectively registered on 21 April 2016, https://en.irct.ir/trial/15600 ).

Keywords: Citrus aurantium; anxiety; aromatherapy; coronary angiography; essential oil; non-drug treatment; randomized controlled trial; single-blind.

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References

    1. Longo DFA, Kasper D, Hauser S, eds. Harrisons principles of internal medicine. 18th ed. New York: McGraw Hill; 2012:350–483.
    1. Mashaykhi NR, Sadrneya S, Chehrei A, Javaheri J, Ahmadlou M. The correlation between serum apolipoprotein A1 and apolipoprotein B with coronary artery disease and its severity. Arak Univ Med Sci J 2013;16:82–89.
    1. Hariri N, Nasseri E, Houshiar-Rad A, Zayeri F, Bondarianzadeh D. Association between altermative healthy eating index and 10-year risk of cardiovascular diseses in male-employees in the public sector in Tehran 1391. Iran J Nutr Sci Food Technol 2013;8:41–50.
    1. Afzali S, Masoudi R, Etemadifar S, Moradi M, Moghaddasi J. The effect of progressive muscle relaxation program (PMR) on anxiety of patients undergoing coronary heart angiography. J Shahrekord Univ Med Sci 2009;11:77–84.
    1. Tahmasbi H, Mahmoodi G, Mokhberi V, Hassani S, Akbarzadeh H, Rahnamai N. The impact of aromatherapy on the anxiety of patients experiencing coronary angiography. Zahedan J Res Med Sci 2012;14:51–55.

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