Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2020 Oct;42(10):2975-2984.
doi: 10.1002/hed.26330. Epub 2020 Jun 23.

Prevalence of human papillomavirus in oral epithelial dysplasia: Systematic review and meta-analysis

Cecilie Dovey de la Cour  1 , Cecilie Dyg Sperling  1 , Federica Belmonte  2 , Stina Syrjänen  3   4 , Freija Verdoodt  1 , Susanne Krüger Kjaer  1   5
Affiliations
Meta-Analysis

Prevalence of human papillomavirus in oral epithelial dysplasia: Systematic review and meta-analysis

Cecilie Dovey de la Cour et al. Head Neck. 2020 Oct.

Abstract

The purpose of this systematic review and meta-analysis was to estimate the overall and type-specific prevalence of human papillomavirus (HPV) DNA in oral epithelial dysplasia and assess p16INK4a overexpression in relation to HPV-status. A systematic literature search identified 31 eligible studies (832 cases) evaluating the presence of HPV DNA in oral epithelial dysplasia cases by PCR. Of these, six studies evaluated p16INK4a overexpression in relation to HPV-status. The overall pooled prevalence of HPV DNA in oral epithelial dysplasia was 27.2% (95% CI: 17.6-38.1). We observed substantial interstudy heterogeneity, which could not be explained by differences in continent, tissue type, or severity of epithelial dysplasia. HPV16 was the predominant genotype detected. Moreover, 62.2% of HPV positive and 17.8% of HPV negative oral epithelial dysplasia samples stained intensively positive for p16INK4a . This meta-analysis found that 27% of oral epithelial dysplasia harbor HPV DNA. Whether this represents a transient infection or has a carcinogenic role is unknown.

Keywords: human papillomavirus; meta-analysis; oral dysplasia; p16; prevalence.

PubMed Disclaimer

References

REFERENCES

    1. de Martel C, Plummer M, Vignat J, Franceschi S. Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int J Cancer. 2017;141(4):664-670.
    1. Ndiaye C, Mena M, Alemany L, et al. HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis. Lancet Oncol. 2014;15(12):1319-1331.
    1. Syrjänen S, Syrjänen K. HPV in head and neck carcinomas: different HPV profiles in Oropharyngeal carcinomas-why? Acta Cytol. 2019;63(2):124-142.
    1. Syrjänen S, Lodi G, von Bultzingslowen I, et al. Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review. Oral Dis. 2011;17(Suppl 1):58-72.
    1. Castellsague X, Alemany L, Quer M, et al. HPV involvement in head and neck cancers: comprehensive assessment of biomarkers in 3680 patients. J Natl Cancer Inst. 2016;108(6):djv403.

Substances

LinkOut - more resources