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. 2020 Jun 1;3(6):e2013075.
doi: 10.1001/jamanetworkopen.2020.13075.

Simulation of Pool Testing to Identify Patients With Coronavirus Disease 2019 Under Conditions of Limited Test Availability

Alhaji Cherif  1 , Nadja Grobe  1 , Xiaoling Wang  1 , Peter Kotanko  1   2
Affiliations

Simulation of Pool Testing to Identify Patients With Coronavirus Disease 2019 Under Conditions of Limited Test Availability

Alhaji Cherif et al. JAMA Netw Open. .

Abstract

This decision analytical model study examines the feasibility of using pool testing to identify patients with coronavirus disease 2019 (COVID-19) in a setting with limited testing availability.

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Conflict of interest statement

Conflict of Interest Disclosures: All authors are employees of the Renal Research Institute, a wholly owned subsidiary of Fresenius Medical Care North America. Dr Kotanko reported owning stock in Fresenius Medical Care.

Figures

Figure.
Figure.. Operating Characteristics of Pooled Testing Stratified by Prevalence
k indicates the number of patients in a pool; and k0 (circles), the optimal pool size at which maximal cost-savings was achieved for various prevalence levels. These examples assumed a test sensitivity of 70%.
See this image and copyright information in PMC

References

    1. Yelin I, Aharony N, Shaer Tamar E, et al. . Evaluation of COVID-19 RT-qPCR test in multi-sample pools. Clin Infect Dis. Published online May 2, 2020;ciaa531. doi:10.1093/cid/ciaa531 - DOI - PMC - PubMed
    1. Dorfman R. The detection of defective numbers of large populations. Ann Math Stat. 1943;14:436-440. doi:10.1214/aoms/1177731363 - DOI
    1. Johnson NL, Kotz S, Wu X. Inspection Errors for Attributes in Quality Control. Chapman and Hall Ltd; 1991. doi:10.1007/978-1-4899-3196-2 - DOI
    1. Wang W, Xu Y, Gao R, et al. . Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. 2020;323(18):1843-1844. doi:10.1001/jama.2020.3786 - DOI - PMC - PubMed
    1. Zou L, Ruan F, Huang M, et al. . SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. 2020;382(12):1177-1179. doi:10.1056/NEJMc2001737 - DOI - PMC - PubMed

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