Improved clinical symptoms and mortality among patients with severe or critical COVID-19 after convalescent plasma transfusion

Abstract

Publisher's Note: There is a Blood Commentary on this article in this issue.

Figure 1.

Laboratory, radiologic, and clinical changes after COVID-19 CCP therapy. (A) Proportion of patients who became virus free after 1 to 3 days, 1 to 7 days, and 1 to 14 days of CCP therapy. (B) Dynamic changes in S-, RBD-, and N-specific IgG levels before and after CCP therapy. (C-E) Dynamic changes in lymphocyte, monocyte, and neutrophil percentages before and after CCP therapy. *P < .05; **P < .01. (F) Dynamic changes in C-reactive protein concentrations before and after CCP therapy. (G) Number and proportion of patients with radiologic improvement after 1 to 3 days, 3 to 7 days, 7 to 10 days, 10 to 14 days, and 14 to 21 days after CCP therapy. RI indicates there were radiologic improvements, and no-RI indicates that no radiologic improvements were observed after CCP therapy. (H) Proportion of patients with an SCSS that decreased within 1 week after CCP therapy. (I) Time to clinical improvement after CCP therapy in patients with different therapy timings. The x-axis represents the number of weeks from symptom onset to CCP therapy. The y-axis represents the number of days from CCP therapy to a 2-point decrease in SCSS. The number of patients at 1 to 4 weeks, 5 to 6 weeks, 7 weeks, and ≥8 weeks was 18, 40, 26, and 50, respectively.