Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep;8(9):e1370.
doi: 10.1002/mgg3.1370. Epub 2020 Jun 23.

Genetic determinants of circulating galectin-3 levels in patients with coronary artery disease

Yu-Huang Liao  1 , Ming-Sheng Teng  2 , Jyh-Ming J Juang  3   4 , Fu-Tien Chiang  3   4   5 , Leay-Kiaw Er  1   6 , Semon Wu  7 , Yu-Lin Ko  2   6   8
Affiliations

Genetic determinants of circulating galectin-3 levels in patients with coronary artery disease

Yu-Huang Liao et al. Mol Genet Genomic Med. 2020 Sep.

Abstract

Background: Galectin-3 plays a crucial role in the regulation of inflammation. The aim of this study was to elucidate the association between LGALS3 genotypes, galectin-3 levels, and inflammatory marker levels in patients with coronary artery disease (CAD).

Results: A total of 474 patients with CAD were enrolled. Significant correlations were discerned between galectin-3 levels and leukocyte counts, C-reactive protein, soluble intercellular adhesion molecule-1, and matrix metalloproteinase 9 levels (all p < .05). The LGALS3 rs2274273, rs4644, rs4652 genotypes, and haplotypes CAC, CCC, and ACT exhibited a significant association with galectin-3 levels (for genotypes, p = 1.05 × 10-25 , 3.54 × 10-25 , and 2.74 × 10-7 , respectively). Multivariate analysis showed LGALS3 rs2274273 and rs4644 genotypes contributing to 20.8% variation of galectin-3 levels. However, there was no association between LGALS3 genotypes and other inflammatory marker levels.

Conclusions: Our data showed strong genetic determinants of galectin-3 levels in patients with CAD. The galectin-3 levels, but not LGALS3 genotypes, were associated with multiple inflammatory marker levels. Further study may be necessary to elucidate the molecular mechanism of galectin-3 in the pathogenesis of chronic inflammatory disorders.

Keywords: CAD; Galectin-3; LGALS3 SNP.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

References

    1. Aksan, G. , Gedikli, Ö. , Keskin, K. , Nar, G. , İnci, S. , Yıldız, S. S. , … Şahin, M. (2016). Is galectin‐3 a biomarker, a player‐or both‐in the presence of coronary atherosclerosis? Journal of Investigative Medicine, 64(3), 764–770. 10.1136/jim-2015-000041 - DOI - PubMed
    1. Bozcali, E. , Polat, V. , Aciksari, G. , Opan, S. , Bayrak, I. H. , Paker, N. , & Karakaya, O. (2014). Serum concentrations of galectin‐3 in patients with cardiac syndrome X. Atherosclerosis, 237(1), 259–263. 10.1016/j.atherosclerosis.2014.09.014 - DOI - PubMed
    1. Califice, S. , Castronovo, V. , & Van Den Brule, F. (2004). Galectin‐3 and cancer (Review). International Journal of Oncology, 25(4), 983–992. - PubMed
    1. Chen, C. , Duckworth, C. A. , Zhao, Q. , Pritchard, D. M. , Rhodes, J. M. , & Yu, L. G. (2013). Increased circulation of galectin‐3 in cancer induces secretion of metastasis‐promoting cytokines from blood vascular endothelium. Clinical Cancer Research, 19(7), 1693–1704. 10.1158/1078-0432.CCR-12-2940 - DOI - PMC - PubMed
    1. Chen, H. J. , Zheng, Z. C. , Yuan, B. Q. , Liu, Z. , Jing, J. , & Wang, S. S. (2012). The effect of galectin‐3 genetic variants on the susceptibility and prognosis of gliomas in a Chinese population. Neuroscience Letters, 518(1), 1–4. 10.1016/j.neulet.2012.02.065 - DOI - PubMed

Publication types