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. 2020 May 22:10:284.
doi: 10.3389/fcimb.2020.00284. eCollection 2020.

Epidemiological and Clinical Characteristics of Patients With Coronavirus Disease-2019 in Shiyan City, China

Long Liu  1 , Xu Lei  1 , Xiao Xiao  1 , Jing Yang  1 , Jian Li  1 , Manshan Ji  1 , Weixing Du  1 , Huabing Tan  1 , Jianyong Zhu  1 , Bei Li  1 , Zhixiong Jin  1 , Weiyong Liu  2 , Jianguo Wu  3 , Zhixin Liu  1
Affiliations

Epidemiological and Clinical Characteristics of Patients With Coronavirus Disease-2019 in Shiyan City, China

Long Liu et al. Front Cell Infect Microbiol. .

Abstract

To investigate the early epidemic of COVID-19, a total of 176 confirmed COVID-19 cases in Shiyan city, Hubei province, China were surveyed. Our data indicated that the rate of emergence of early confirmed COVID-19 cases in Hubei province outside Wuhan was dependent on migration population, and the second-generation of patients were family clusters originating from Wuhan travelers. Epidemiological investigation indicated that the reproductive number (R0) under containment strategies was 1.81, and asymptomatic SARS-CoV-2 carriers were contagious with a transmission rate of 10.7%. Among the 176 patients, 53 were admitted to the Renmin Hospital of Hubei University of Medicine. The clinical characteristics of these 53 patients were collected and compared based on a positive RT-PCR test and presence of pneumonia. Clinical data showed that 47.2% (25/53) of COVID-19 patients were co-infected with Mycoplasma pneumoniae, and COVID-19 patients coinfected with M. pneumoniae had a higher percentage of monocytes (P < 0.0044) and a lower neutrophils percentage (P < 0.0264). Therefore, it is important to assess the transmissibility of infected asymptomatic individuals for SARS-CoV-2 transmission; moreover, clinicians should be alert to the high incidence of co-infection with M. pneumoniae in COVID-19 patients.

Keywords: COVID-19; Mycoplasma pneumonia; SARS-CoV-2; asymptomatic infections; coinfection.

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Figures

Figure 1
Figure 1
The population migration and confirmed COVID-19 cases in Hubei province outside Wuhan. Flow of population migration from Wuhan to other cities in Hubei province between January 10 and January 24, 2020, during the “Chunyun” period. Data of COVID-19 cases were collected from the Chinacdc.com.
Figure 2
Figure 2
Analysis of the population migration and trend of illness onset. (A) Geographical display of the distance of Shiyan from Wuhan. The migrant population is calculated using the percent of total migrated individuals. (B) The onset numbers of confirmed COVID-19 patients in Hubei province and Shiyan city. Deaths occurred up to February 11, 2020 in Hubei province were also counted.
Figure 3
Figure 3
Contact history analysis of the 176 confirmed cases. (A) The contact history was obtained by patients or family members, and the duration spanned 14 days before symptom onset. Stars indicate the 12 cases after contact with infected asymptomatic carriers. (B) Twelve patients (primary infection, PI) infected by asymptomatic carriers (AC) from Wuhan; the secondary infections (SI) were surveyed. Eleven asymptomatic infections caused 12 primary infections and four secondary infections.
Figure 4
Figure 4
Survey of the close contacts of 176 confirmed cases. The close contacts mainly included family members, colleagues, or friends who lived together, shared meals, and/or physically communicated with the confirmed COVID-19 patients 2 days before the onset of illness. The close contacts were interviewed.
Figure 5
Figure 5
Transverse chest computed tomography images of patients with COVID-19. Transverse chest computed tomography of six patients with COVID-19 on admission showed bilateral or multiple lobular or subsegmental areas of consolidation or bilateral ground glass opacity.
See this image and copyright information in PMC

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