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Review
. 2020 May 15:7:240.
doi: 10.3389/fmed.2020.00240. eCollection 2020.

May Polyphenols Have a Role Against Coronavirus Infection? An Overview of in vitro Evidence

Giuseppe Annunziata  1 , Marco Sanduzzi Zamparelli  2 , Ciro Santoro  3 , Roberto Ciampaglia  1 , Mariano Stornaiuolo  1 , Gian Carlo Tenore  1 , Alessandro Sanduzzi  4   5 , Ettore Novellino  1
Affiliations
Review

May Polyphenols Have a Role Against Coronavirus Infection? An Overview of in vitro Evidence

Giuseppe Annunziata et al. Front Med (Lausanne). .

Abstract

The coronavirus infection is constantly diffusing worldwide and the incidence of death is dramatically increasing, representing one of the greatest disasters in human history. Nowadays, no effective therapeutic approaches have been licensed, despite the rising interest of the scientific research in this specific field, and the daily growing number of publications, while the need to find novel strategies is urgent. Evidence in the literature reported the antiviral activity of polyphenols, the largest class of bioactive compounds in nature. Interestingly, a limited number of studies investigated the efficacy of polyphenols from different raw materials, directly against coronaviruses. The present manuscript aimed to report this evidence and provide a viewpoint on the possibility to use it as a start point for the development of novel natural approaches against this viral infection, eventually designing further appropriate researches.

Keywords: COVID-19 pandemic; SARS-CoV2; antiviral; nutraceutical; polyphenols.

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Figures

Figure 1
Figure 1
Resveratrol (C14H12O3). (A) Trans-resveratrol; (B) cis-resveratrol.
Figure 2
Figure 2
Forsythoside A (C29H36O15).
Figure 3
Figure 3
Polyphenols isolated from Brussonetia papyrifera. (A) Broussochalcone B (C20H20O4); (B) broussochalcone A (C20H20O5); (C) kazinol A (C25H30O4); (D) 3'-(3-methylbut-2-enyl)-3',4,7-trihydroxyflavone (C20H22O4); (E) papyriflavonol A (C25H26O7); (F) 4-hydroxyisolonchocarpin (C20H20O4); (G) kazinol B (C25H28O4); (H) broussoflavan A (C25H30O6); (I) kazinol F (C25H32O4); (J) kazinol J (C26H34O4).
Figure 4
Figure 4
Catechins. (A) (-)-catechin gallate (C22H18O10); (B) (-)-gallocatechin (C22H18O11).
See this image and copyright information in PMC

References

    1. Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, et al. . Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. (2020) 26:502–5. 10.1038/s41591-020-0817-4 - DOI - PMC - PubMed
    1. Pan Y, Zhang D, Yang P, Poon LLM, Wang Q. Viral load of SARS-CoV-2 in clinical samples. Lancet Infect Dis. (2020) 20:411–2. 10.1016/S1473-3099(20)30113-4 - DOI - PMC - PubMed
    1. Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, et al. . SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. (2020) 382:1177–9. 10.1056/NEJMc2001737 - DOI - PMC - PubMed
    1. Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, et al. . A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19. N Engl J Med. (2020) 382:1787–99. 10.1056/NEJMoa2001282 - DOI - PMC - PubMed
    1. Clinicaltrials.Gov (2020). Adaptive COVID-19 Treatment Trial. Available online at: https://clinicaltrials.gov/ct2/show/NCT04280705?term=remdesivir&cond=cov... (accessed March 27, 2020).