Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep;81(3):e90-e92.
doi: 10.1016/j.jinf.2020.06.024. Epub 2020 Jun 20.

Persistent positivity and fluctuations of SARS-CoV-2 RNA in clinically-recovered COVID-19 patients

Affiliations

Persistent positivity and fluctuations of SARS-CoV-2 RNA in clinically-recovered COVID-19 patients

Valeria Cento et al. J Infect. 2020 Sep.
No abstract available

Keywords: COVID-19; Coronavirus; Hospital discharge; Molecular diagnosis; Pandemic; RT-PCR; SARS-CoV-2.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Snapshots of nasopharyngeal SARS-CoV-2 RNA detection by RT-PCR after hospital discharge. The results of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) real-time PCR (RT-PCR) on nasopharyngeal swabs are reported at different time-intervals after hospital discharge, for patients who recovered from Coronavirus Disease 2019 (COVID-19). The total number of nasopharyngeal swabs processed are also reported (blue line). RT-PCR was performed d by AllplexTM 2019-nCoV assay (Seegene) and Cobas SARS-CoV-2 assay (Roche Diagnostics). Positive RT-PCR results are defined by the detection of at least two of three target genes (N, E and RdRP genes), while weakly positive RT-PCR results are defined by the detection of one of them.

References

    1. ECDC . ECDC. 2020. European Centre for Disease Prevention and Control. Guidance for discharge and ending isolation in the context of widespread community transmission of COVID-19, 8 April 2020. Stockholm.https://www.ecdc.europa.eu/sites/default/files/documents/covid-19-guidan... Available from.
    1. Peng J., Wang M., Zhang G., Lu E. Seven discharged patients turning positive again for SARS-CoV-2 on quantitative RT-PCR. Am J Infect Control. 2020 Apr 10 PubMed PMID: 32317126. Pubmed Central PMCID: 7151314. - PMC - PubMed
    1. Fu W., Chen Q., Wang T. Letter to the Editor: three cases of re-detectable positive SARS-CoV-2 RNA in recovered COVID-19 patients with antibodies. J Med Virol. 2020 May 5 PubMed PMID: 32369214. - PMC - PubMed
    1. Woodruff A. COVID-19 follow up testing. J Infect. 2020 May 11 PubMed PMID: 32407758. Pubmed Central PMCID: 7212964. - PMC - PubMed
    1. Liu W.D., Chang S.Y., Wang J.T., Tsai M.J., Hung C.C., Hsu C.L. Prolonged virus shedding even after seroconversion in a patient with COVID-19. J Infect. 2020 Apr 10 PubMed PMID: 32283147. Pubmed Central PMCID: 7151379. - PMC - PubMed