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Comment
. 2020 Sep:110:154300.
doi: 10.1016/j.metabol.2020.154300. Epub 2020 Jun 20.

Letter to the editor: Immunomodulation by phosphodiesterase-4 inhibitor in COVID-19 patients

Affiliations
Comment

Letter to the editor: Immunomodulation by phosphodiesterase-4 inhibitor in COVID-19 patients

Alessandro Santaniello et al. Metabolism. 2020 Sep.
No abstract available

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Conflict of interest statement

Declaration of competing interest The authors declare no conflict of interest.

Comment on

References

    1. Dalamaga M., Karampela I., Mantzoros C.S. Commentary: phosphodiesterase 4 inhibitors as potential adjunct treatment targeting the cytokine storm in COVID-19 [published online ahead of print, 2020 Jun 1] Metabolism. 2020;109:154282. doi: 10.1016/j.metabol.2020.154282. - DOI - PMC - PubMed
    1. Wu Z., McGoogan J.M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72,314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020 doi: 10.1001/jama.2020.2648. [published online ahead of print, 2020 Feb 24] - DOI - PubMed
    1. Tay M.Z., Poh C.M., Rénia L., MacAry P.A., LFP Ng. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol. 2020:12. doi: 10.1038/s41577-020-0311-8. [published online ahead of print, 2020 Apr 28] - DOI - PMC - PubMed
    1. Schafer P.H., Parton A., Gandhi A.K. Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis. Br J Pharmacol. 2010;159(4):842–855. doi: 10.1111/j.1476-5381.2009.00559.x. - DOI - PMC - PubMed
    1. Imam F., Al-Harbi N.O., Al-Harbi M.M. Apremilast ameliorates carfilzomib-induced pulmonary inflammation and vascular injuries. Int Immunopharmacol. 2019;66:260–266. doi: 10.1016/j.intimp.2018.11.023. - DOI - PubMed

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