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Meta-Analysis
. 2021 Feb 1;72(3):521-533.
doi: 10.1093/cid/ciaa828.

Clinical Presentation and Outcomes of Pregnant Women With Coronavirus Disease 2019: A Systematic Review and Meta-analysis

Reem Matar  1 , Layan Alrahmani  2   3 , Nasser Monzer  4 , Labib G Debiane  5 , Elie Berbari  6 , Jawad Fares  7 , Fidelma Fitzpatrick  8   9 , Mohammad H Murad  10
Affiliations
Meta-Analysis

Clinical Presentation and Outcomes of Pregnant Women With Coronavirus Disease 2019: A Systematic Review and Meta-analysis

Reem Matar et al. Clin Infect Dis. .

Abstract

Background: Descriptions of coronavirus disease 2019 (COVID-19) have focused on the nonpregnant adult population. This study aims to describe the clinical characteristics and perinatal outcomes of COVID-19 in pregnancy.

Methods: We searched databases from December 2019 to 30 April 2020. Eligible studies reported clinical characteristics, radiological findings, and/or laboratory testing of pregnant women during infection. Data were pooled across studies using a random-effects model.

Results: Twenty-four studies (136 women) were included. The most common symptoms were fever (62.9%) and cough (36.8%). Laboratory findings included elevated C-reactive protein (57%) and lymphocytopenia (50%). Ground-glass opacity was the most common radiological finding (81.7%). Preterm birth rate was 37.7% and cesarean delivery rate was 76%. There was 1 maternal death. There were 2 fetal COVID-19 cases.

Conclusions: The clinical picture in pregnant women with COVID-19 did not differ from the nonpregnant population; however, the rate of preterm birth and cesarean delivery are considerably higher than international averages.

Keywords: coronavirus; neonates; pregnant; transmission.

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Figures

Figure 1.
Figure 1.
Forest plot of the clinical characteristics present at time of admission. Abbreviations: CI, confidence interval; Ev, xxx; Trt, xxx.
Figure 2.
Figure 2.
Forest plot of the laboratory findings present at time of admission. Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; CI, confidence interval.
Figure 3.
Figure 3.
Forest plot of the radiological findings present at time of admission. Abbreviations: CI, confidence interval; Ev, xxx; Trt, xxx.
Figure 4.
Figure 4.
Forest plot of neonatal laboratory findings present after birth. Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; CI, confidence interval.
Figure 5.
Figure 5.
Forest plot of neonatal outcomes after birth. Abbreviations: CI, confidence interval; COVID-19, coronavirus disease 2019; NICU, neonatal intensive care unit.
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